Thiago Carvalho

I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com

Public Key

npub1xakev87fgm9edqu6f5jhszwunekjxl3dpnq4sxvm3nzu2ace8xnqyczham

NIP-05 Address

cyrilpedia_at_qoto.org@mostr.pub

Profile Code

nprofile1qqsrwmvkrly5djukswdy6ftcp8wfumfr0ckses2crxdce3w9wuvnnfspz4mhxue69uhhyetvv9ujumt0wd68ytnsw43qyy6r4f

Publishing to

relay.mostr.pub

Author Public Key

npub1xakev87fgm9edqu6f5jhszwunekjxl3dpnq4sxvm3nzu2ace8xnqyczham

Show more details

Last Notes

2024-08-17 11:15:08

'The drip, drip of casual racism, edgelord bigotry, bad-faith polemics, dog whistles, crass disinformation, dodgy pornbots, cynical grifting, tin-hat conspiracies and tiresome crypto bollocks became too much for some users of the site formerly known as Twitter fairly soon after Musk bought it in October 2022, later changing its name to X. '
https://www.ft.com/content/3edd3caf-05f5-4e65-a8ba-f86481ddc0e9

2024-07-22 07:36:10

'We unexpectedly found that cRel abundance and B cell proliferation are not proportional, but have a complex relationship in which some characteristics of proliferative clonal expansion are enhanced by cRel but others are diminished. We show that this may underlie the proliferation phenotypes of marginal zone vs. follicular B cell subsets.'
#Immunology
https://www.pnas.org/doi/10.1073/pnas.2309686121

2024-07-22 07:21:51

'In many European capitals, the average rent for a one-bedroom apartment is more than the median income of a young person. In 2023, houses in the UK were more expensive than they’d been since 1876. In the United States, home prices are up 60 percent over the last decade.'
https://jacobin.com/2024/07/housing-crisis-homelessness-financialization/

2024-07-22 07:18:33

'In this review of a diverse literature, we show how host control mechanisms influence almost every aspect of microbiome biology. Our focus is the mammalian microbiome, but we also examine well-characterized examples from invertebrate and plant microbiomes. To begin, we explore the biology of host control, including immunity, barrier function, physiological homeostasis, transit, and host behavior.'
https://www.science.org/doi/10.1126/science.adi3338

2024-07-22 07:17:00

'While Japan lacks its own homegrown AI giants, some tech companies are drawn to the market for another reason: the country’s copyright law which critics say allows widespread use of copyrighted images and other materials for commercial purposes to train AI models without seeking permission.'
https://www.ft.com/content/f9e7f628-4048-457e-b064-68e0eeea1e39

2024-07-21 11:05:40

'Our results imply that nervous systems converged onto synaptic density invariance to stabilise neuronal responses, suggesting a simplifying principle for neural circuit function, assembly and evolution.'
#Neuroscience #Preprint
https://www.biorxiv.org/content/10.1101/2024.07.18.604056v1?med=mas

2024-07-21 10:29:48

"I would also like to thank the various astronomers who forgot to collect their desserts from the fridge over the years (they were not wasted).
Roberto Soria
'Accretion processes in black-hole binaries (1999)'"
https://science.anu.edu.au/news-events/news/unexpected-poetry-phd-acknowledgements#testtube-quote-7

2024-07-21 10:25:41

'Combining our amphioxus dataset and publicly available data from the mouse, zebrafish, tunicate, sea urchin and sea anemone, we uncovered a tripartite origin of the chordate CNS from anterior, posterior and NMP populations (Extended Data Fig. 7c).'
https://www.nature.com/articles/s41559-024-02469-7#Sec10
https://media.social.qoto.org/media_attachments/files/112/823/994/824/077/949/original/cb45da62d736692c.png

2024-07-21 10:19:17

'We discovered that the Neisseria gonorrhoeae transcriptional response to PMNs has features in common with the transcriptional response to nutrient metals and oxidative stress, which enhance Neisseria gonorrhoeae resistance to hydrogen peroxide & polymorphonuclear leukocytes.'
#Immunology #HostPathogen
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012369#sec010

2024-07-21 09:13:10

'In the end, Bell Labs was ultimately undermined by the very technologies that it had created. The world that Bell Labs thrived in no longer exists: to push technological progress forward, we'll need to understand both why Bell Labs worked and why it no longer could.'
(via The Browser)
https://www.construction-physics.com/p/what-would-it-take-to-recreate-bell?ref=thebrowser.com

2024-07-21 08:42:23

'Different versions of this horror have happened again and again in history. They’re still happening in places like Rwanda, Bosnia, Kosovo and East Timor, wherever one group of people permits its leaders to convince them that for their own protection, for the safety of their families and the security of their country, they must get their enemies, those alien others who until now were their neighbors.'
https://commongood.cc/reader/a-few-rules-for-predicting-the-future-by-octavia-e-butler/

2024-07-21 08:10:53

'Researchers performed a systematic assessment of the circular DNA structures by analysing more than 2,500 plasmids produced in labs and sent to a company that provides services such as packaging the structures inside viruses so they can be used as gene therapies. The team found that nearly half of the plasmids had design flaws, including errors in sequences crucial to expressing a therapeutic gene.'
https://www.nature.com/articles/d41586-024-02280-1

2024-07-21 08:06:23

'As instituições são quem definitivamente não está a fazer o que devia. Ou seja, investigar estes casos e garantir que há consequências. Muitas vezes, as instituições tentam varrer para debaixo do tapete e concluem que não houve qualquer má conduta.'
https://www.publico.pt/2024/07/21/ciencia/entrevista/vezes-instituicoes-tentam-varrer-fraude-cientifica-debaixo-tapete-2097794

2024-07-20 16:08:09

'Consistent with previous results, most candidate SNPs were in putatively regulatory regions. Genes that contained the most extreme outliers relate to traits such as body weight or size, metabolism, immunity, fat, eye function, and the cardiovascular system'
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011036

2024-07-20 10:45:09

'Tis the season
Fa-la-la-la-la, la-la-la-la
https://media.social.qoto.org/media_attachments/files/112/818/409/074/397/690/original/3f13963c28912c76.jpeg

2024-07-20 09:31:24

'Here, we established a mouse model of sexual dimorphism during GI colonization by MRSA. Our results show that in contrast to male mice that were susceptible to persistent colonization, female mice rapidly cleared MRSA from the GI tract following oral inoculation in a manner dependent on the gut microbiota.'
#Immunology #Preprint #MucosalImmunology
https://www.biorxiv.org/content/10.1101/2024.07.17.603994v1

2024-07-20 09:04:43

'Yet the tyrant might be less important than the oligarchs behind him. Whereas Trump can slip through the gaps of the legal system, his backers waltz through the cellophane barrier between money and politics. The right metric for predicting Trump’s vice-presidential pick was simple: what do these supporters want?'
https://www.ft.com/content/a7eea0af-bf9f-4635-812b-271c30620e72

2024-07-20 08:59:12

“I am interested in late plays,” says director Tamara Harvey, as she settles into a seat in the gracious wood-panelled rehearsal room of the Royal Shakespeare Company’s Swan Theatre. “Something happens in some writers where they’ve had their big hits and they get to a point of devil-may-care — you can feel a confidence and a defiance in the writing.”
https://www.ft.com/content/54a23ba4-7308-4cfc-b9b7-2e04f5afd123

2024-07-20 08:26:57

"Authors have expressed their shock after the news that academic publisher Taylor & Francis, which owns Routledge, had sold access to its authors’ research as part of an Artificial Intelligence (AI) partnership with Microsoft—a deal worth almost £8m ($10m) in its first year."
https://www.thebookseller.com/news/academic-authors-shocked-after-taylor--francis-sells-access-to-their-research-to-microsoft-ai

2024-07-20 08:25:09

'The Centers for Disease Control and Prevention once advised five days of isolation after a positive Covid test, followed by five days of masking when out in public. That is still a reasonable approach, Dr. Barouch said. “It’s believed that after about five days, then contagiousness goes down substantially,” he said, though that “doesn’t necessarily mean every single person on day six would not be contagious.”'
https://www.nytimes.com/2024/07/18/well/covid-contagious-period.html

2024-07-20 08:08:35

'Jackie’s son was one of 171 people sickened and 22 hospitalized from September 2023 to March 2024 in a salmonella outbreak linked to unpasteurized milk from Raw Farm, according to the California Department of Public Health.'
https://www.nytimes.com/2024/07/19/well/raw-milk-health-salmonella.html

2024-07-20 07:53:35

'Pluvicto is one of a new generation of so-called “radiopharmaceutical” therapies that can help cancer patients live longer, but are expensive to produce due to complex supply chains. The US list price of the drug is about $42,500 a dose, with a treatment cycle of up to six doses, but it is not offered by some European health systems.'
https://www.ft.com/content/1a1910e5-fd95-45f9-b8fd-adc4d7b3c8e7

2024-07-19 06:49:23

'The United States now has the highest rate of new syphilis infections since 1950, the Centers for Disease Control and Prevention reported in January. In 2022, the last year for which data are available, there were 1.6 million cases of chlamydia and nearly 650,000 new cases of gonorrhea.'
https://www.nytimes.com/2024/07/18/health/doxycycline-sti.html

2024-07-18 09:31:49

'I was particularly impressed by the marketing department at Columbia Pictures, which asserted, on reflection, that “E.T.” would have “limited audience appeal.” (Spielberg took the film to Universal.)'
https://www.newyorker.com/magazine/2024/07/22/the-future-was-now-chris-nashawaty-book-review

2024-07-18 09:13:52

'The students in Lisbon worked with what they had, publishing poetry, essays, short stories, news of daily life and events at the Casa. The magazine ran on and off between 1948 and 1964 in difficult conditions. It was impossible to write anything explicitly anticolonial without reprisal. The magazine was closely (if crudely) surveilled, and many of its writers were imprisoned. But keen readers could read between the lines.'
https://www.lrb.co.uk/blog/2024/july/a-real-magazine

2024-07-18 07:39:27

'If her unconditional support for Volodymyr Zelenskiy in the Ukraine war has been praised by experts as a step in the right direction, her equally unconditional support for Israel’s Benjamin Netanyahu drew intense criticism, including from the EU foreign affairs chief Josep Borrell, who defined von der Leyen’s unilateral actions as carrying “a high geopolitical cost for Europe”.
https://www.theguardian.com/commentisfree/article/2024/jul/17/ursula-von-der-leyen-europe-second-term

2024-07-18 07:33:39

'As mice age, IL-11 is upregulated across cell types and tissues to regulate an ERK–AMPK–mTORC1 axis to modulate cellular, tissue- and organismal-level ageing pathologies. Deletion of Il11 or Il11ra1 protects against metabolic decline, multi-morbidity and frailty in old age.'
#Immunology
https://www.nature.com/articles/s41586-024-07701-9

2024-07-18 07:27:07

'Brâncuși treasured his tools. “When you finish a work,” he wrote, “you must let your tools rest, so that they invite you to continue the following day. Otherwise, they will pass on their tiredness to you, or get angry.”
https://www.nybooks.com/online/2024/07/16/the-sculptor-of-flight-brancusi/

2024-07-18 07:25:46

'The cumulative incidence of PASC during the first year after SARS-CoV-2 infection decreased over the course of the pandemic, but the risk of PASC remained substantial even among vaccinated persons who had SARS-CoV-2 infection in the omicron era.'
#Covid #Covid19 #LongCovid #SARSCoV2
https://www.nejm.org/doi/full/10.1056/NEJMoa2403211

2024-07-18 07:20:58

“Psilocybin, in contrast to any other drug we’ve tested, has this massive effect on the whole brain that was pretty unexpected,” said Dr. Nico Dosenbach, a professor of neurology at Washington University and a senior author of the study. “It was quite shocking when we saw the effect size.”
https://www.nytimes.com/2024/07/17/health/psilocybin-psychedelic-mushrooms-brain.html

2024-07-18 07:04:24

'The exhibition focuses on a dark period from Greece’s recent past, when democracy briefly floundered. In common with its southern European neighbours, Spain and Portugal, Greece found itself, in the seven years between 1967 and 1974, ruled by a military regime.'
https://www.ft.com/content/86e957db-f5cc-4083-a490-6250af61bfe7

2024-07-17 14:41:44

'Yet there is another feature that is almost never viewed as a problem in “respectable circles” in Germany, or elsewhere: its huge structural savings surpluses, which have, of course, financed its huge current account surpluses. Many German economists view these as proof of Germany’s international competitiveness and insist that everybody else, especially in the Eurozone, should follow its example. This is nonsense.'
https://www.ft.com/content/2135f8c7-dd60-463c-9bd5-5a907d5f8f1e

2024-07-17 14:23:09

'We have found that the severity of SARS-CoV-2 infection in mice can be dramatically reduced by the catalytic reduction of mROS through the action of the mCAT transgene, or treatment with the mitochondrially targeted catalytic antioxidant drug, EUK8.'
https://www.pnas.org/doi/10.1073/pnas.2321972121#sec-2

2024-07-17 14:02:16

'Há quase 3000 contratos precários de investigadores em instituições científicas, ou seja, contratos a termo com um fim previsto para os próximos anos. Destes contratos, há 1607 vínculos de cientistas que terminarão até 2026 e que, no próximo ano e meio, terão de encontrar soluções se quiserem continuar um trajecto enquanto investigadores.'
https://www.publico.pt/2024/07/17/ciencia/noticia/1500-contratos-precarios-cientistas-terminam-ate-2026-2097357

2024-07-17 09:49:06

'When I was starting my group, I was reading advice on Twitter. A lot wasn't very useful, but somebody asked, ‘What is the single most important advice to a new PI?’ Somebody answered that it was to ‘grow slowly’, and I couldn't agree more. I tried to take the same approach: I will only hire someone in my lab if I'm absolutely sure they'll be a good fit. I think that has worked well so far.'
https://journals.biologists.com/dev/article/150/12/dev202032/319909/Transitions-in-development-an-interview-with

2024-07-17 09:46:38

'The SNSF Swiss Postdoctoral Fellowships 2024 call document is already available. The other relevant documents (Instructions for submitting an application via mySNF and the Research Plan Template) will be updated and published by 2 September 2024 when the call for proposals opens.'
https://www.snf.ch/en/m1NtWp4nTELQixlu/funding/horizon-europe-swiss-postdoctoral-fellowships

2024-07-17 09:18:48

'The Electronic Bard is not easy for Trurl to make. In thinking about how to program it, Trurl reads “twelve thousand tons of the finest poetry” but deems the research insufficient. As he sees it, the program found in the head of even an average poet “was written by the poet’s civilization, and that civilization was in turn programmed by the civilization that preceded it, and so on to the very Dawn of Time.” The complexity of the average poet-machine is daunting.'
https://www.newyorker.com/science/elements/thinking-about-ai-with-stanislaw-lem

2024-07-17 08:59:39

'Women taking the anti-diabetes medication Ozempic might have an extra reason to pat their tummies. Not only does the injectable drug lead to weight loss, a finding that has sparked frenzied off-label demand worldwide, but in recent months it has also been linked to a surprise baby boom.'
https://www.ft.com/content/bf52faa7-9428-450f-a1f6-69fde3fa4c51

2024-07-17 08:51:57

'The Court of Justice of the European Union has ruled today that the European Commission did not give the public “sufficiently wide access” to Covid-19 vaccine contracts, finding irregularities in its justification for redacting parts of the documents.'
https://www.politico.eu/article/eus-top-court-rules-against-european-commission-in-vaccine-contracts-transparency-case/

2024-07-17 07:18:14

'Por muito que as escolas públicas em meios desfavorecidos tenham os melhores professores, mais motivados e com o melhor plano de estudos, nunca conseguirão competir com as dos filhos da elite económica e cultural dos bairros mais abastados de Lisboa ou Porto. Uma escola que leva alunos em contextos muitíssimo desfavoráveis até ao 12º ano tende a ser melhor do que a escola que põe filhos de licenciados na Universidade.'
https://expresso.pt/opiniao/2024-07-17-ao-ranking-do-privilegio-junta-se-a-vantagem-da-batota-e7ce8613

2024-07-16 14:21:16

'I also found my modus operandi in Australia: sweatily tracking rehabilitated koalas in the bush several days a week, while deploying molecular tools in the lab to analyze mucosal samples on the remaining days of the week. A ‘wild immunologist’ was born!'
#Immunology
https://www.cell.com/current-biology/fulltext/S0960-9822(24)00802-9

2024-07-16 14:12:33

'Dr. Bengt Samuelsson, a biochemist who shared the 1982 Nobel Prize in medicine for helping to define the biological activities of potent hormone-like molecules in the body called prostaglandins, and whose breakthrough discoveries led to drugs that treat inflammation, glaucoma and allergies, died on July 5 at his home in Molle, on the west coast of Sweden. He was 90.'
https://www.nytimes.com/2024/07/15/science/bengt-samuelsson-dead.html

2024-07-16 13:59:18

'Japan now counts over a thousand varieties of miso, and each region is synonymous with a local recipe: Edo sweet red miso in Tokyo (the city being previously known as Edo) and sweet white miso in Kyoto. In the Chūkyō region it’s dark brown and bitter; in Kyushu it’s made with barley (mugi). As Kazutoshi Endo, chef-patron of the Michelin-starred London sushi restaurant Endo at the Rotunda, puts it, “miso equals culture”.'
https://www.theguardian.com/food/article/2024/jul/16/the-miso-miracle-how-to-use-the-ingredient-that-makes-every-dish-delicious

2024-07-16 06:33:12

'Buxtun is revered as a hero to public health scholars and ethicists for his role in bringing to light the most notorious medical research scandal in U.S. history. Documents that Buxtun provided to The Associated Press, and its subsequent investigation and reporting, led to a public outcry that ended the study in 1972.'
https://www.seattletimes.com/seattle-news/health/tuskegee-syphilis-study-whistleblower-peter-buxtun-has-died-at-age-86/?utm_source=RSS&utm_medium=Referral&utm_campaign=RSS_seattle-news

2024-07-16 06:28:53

'With Aeschylus, it’s a happy ending. There’s peace. Orestes is pardoned. But Euripides takes the same plot and writes it in a completely contrary way. Orestes is not pardoned. He and Electra are condemned to death by stoning. They run amok, storm the palace and burn the whole city down. It reminds me a lot of the storming of the U.S. Capitol. We have the dream of Aeschylus and the nightmare of Euripides. It’s like pieces of a puzzle that don’t fit together, and that interests me.'
https://www.nytimes.com/2024/07/13/arts/salzburg-festival-greek-tragedy.html

2024-07-15 16:04:50

'That potential has not materialized. Just 19 stem-cell transplants using a child’s own cord blood have been reported since 2010, according to the Center for International Blood and Marrow Transplant Research. Newer research has led many doctors to abandon cord blood in favor of adult stem cells.'
https://www.nytimes.com/2024/07/15/health/cord-blood-storage-contamination.html

2024-07-15 13:03:05

The intracellular Fc receptor strikes again:
"Mechanistic studies revealed that TTCM2-ms cleared intracellular, synaptic, and seed-competent tau aggregates through tripartite motif-containing 21 (TRIM21), an intracellular antibody receptor and E3 ubiquitin ligase known to facilitate proteasomal degradation of cytosolic antibody-bound proteins. TRIM21 was found to be essential for TTCM2-ms–mediated clearance of tau pathology."
https://www.science.org/doi/full/10.1126/scitranslmed.adj5958

2024-07-15 13:00:55

'Over the four-week tournament, football fans from England to Georgia discovered often to their surprise just how unreliable the trains were. “If it wasn’t already clear, the [experience during the] Euros showed just what a problem Deutsche Bahn has with reliability and punctuality”
https://www.theguardian.com/world/article/2024/jul/15/germany-close-key-rail-corridor-overhaul-train-network-deutsche-bahn

2024-07-15 10:31:36

'A situação em Gaza é inimaginável e a inação da União Europeia compromete a sua credibilidade como agente de paz. Para construir a paz na Europa, a União Europeia precisa de um discurso sério e coerente sobre a paz, para ser levada a sério pelo mundo.'
https://www.tsf.pt/61549809/catarina-martins-a-tsf-uniao-europeia-tem-dois-pesos-e-duas-medidas-nos-varios-conflitos/

2024-07-15 10:30:57

'A situação em Gaza é inimaginável e a inação da União Europeia compromete a sua credibilidade como agente de paz. Para construir a paz na Europa, a União Europeia precisa de um discurso sério e coerente sobre a paz, para ser levada a sério pelo mundo.'
@catarinamartins.bsky.social
https://www.tsf.pt/61549809/catarina-martins-a-tsf-uniao-europeia-tem-dois-pesos-e-duas-medidas-nos-varios-conflitos/

2024-07-15 09:55:43

'In this article, we discuss the potential role of N-of-1 trials in cancer drug development in the era of personalized cancer medicine. We also elaborate on a suggested modified design for N-of-1 trials able to overcome limitations and make this concept more applicable to clinical oncology.'
https://aacrjournals.org/cancerdiscovery/article/13/6/1301/726949/N-of-1-Trials-in-Cancer-Drug-Development

2024-07-15 09:44:12

'We pair this with a discussion about who has the power to make these changes, from funders to administrators to teachers and people outside of academia. The aim is to teach students that there are people behind the decisions and priorities of academia and research, and thus these issues can be addressed by getting the right people involved.'
https://onlinelibrary.wiley.com/doi/10.1002/jcp.31352?utm_medium=email&utm_source=substack

2024-07-15 08:03:22

"HuR is a crucial regulator of glutaminase RNA metabolism in breast cancer that affects different aspects of mRNA metabolism, such as mRNA stability and splicing. Overall, HuR coordinates glutamine metabolism through the TCA cycle, and its depletion renders cells more dependent on glutamine for growth and migration and more sensitive to glutaminase inhibition."
https://www.nature.com/articles/s41467-024-49874-x#Sec10

2024-07-15 07:58:46

'Meanwhile, since 2005, more than two thousand dogs have been successfully cloned. Biologically, their genesis is not very different from that of cloned cows or sheep, but in other respects the cloning of pets is far more uncanny.'
https://www.newyorker.com/magazine/2024/07/01/would-you-clone-your-dog

2024-07-15 07:56:14

'(...) Enger was later arrested and sentenced to six years and three months, Norway’s longest-ever stretch for theft. Hill joked: “‘The Scream’ was stolen by a bunch of Oslo no-hopers. I suppose you could say it was Norwegian organised crime: two men and a ladder.”
https://www.ft.com/content/30c7f586-e3bd-445c-af55-d46814283d60

2024-07-15 07:31:44

'Lisbon-based Somai Pharmaceuticals, which is involved in the extraction, development and distribution of medical cannabis products, is seeking €250mn as a “reasonable” valuation in a Nasdaq IPO, with a secondary listing on the Toronto Stock Exchange or the LSE, said chief executive Michael Sassano.'
https://www.ft.com/content/e5e099b5-d7c9-4281-b370-79cb437459e6

2024-07-15 07:03:28

'Correlation is not causation: this simple and uncontroversial statement has far-reaching implications. Defining and applying causality in biomedical research has posed significant challenges to the scientific community. In this perspective, we attempt to connect the partly disparate fields of systems biology, causal reasoning, and machine learning to inform future approaches in the field of systems biology and molecular medicine'
https://www.embopress.org/doi/full/10.1038/s44320-024-00041-w

2024-07-14 16:50:40

'Academics researching online misinformation in the US are learning a hard lesson: Academic freedom cannot be taken for granted. They face a concerted effort—including by members of Congress—to undermine or silence their work documenting false and misleading internet content. The claim is that online misinformation researchers are trying to silence conservative voices. The evidence suggests just the opposite.'
https://www.science.org/doi/10.1126/science.adr3820

2024-07-14 16:36:51

'The goal must be to ensure that people of color have fair access to the full array of medical treatments and resources available, said Dr. David Jones, a Harvard professor who has been a leading proponent of removing race from clinical algorithms.
But critics of the Apgar score’s reliance on skin color fear that it is resulting in extra medical treatment being heaped on babies of color who are healthy, potentially sending them to intensive care unnecessarily.'
https://www.nytimes.com/2024/07/13/health/apgar-score-black-infants.html

2024-07-14 16:33:59

'Apesar da retórica popular, a União Nacional (RN) opôs-se ao aumento dos salários médios e mínimo, optando por propor a redução das contribuições para a Segurança Social, e defendeu menos regras ambientais. Como nos anos 30, a chegada dos fascistas ao poder teria o amparo do dinheiro.'
https://expresso.pt/opiniao/2024-07-11-a-desdemocratizacao-da-democracia-65133d3f

2024-07-14 16:16:51

'Twenty-nine different Car-T treatments for autoimmune diseases, ranging from the muscle inflammation condition myositis to multiple sclerosis, are now being tested in clinical trials by drugmakers including Novartis and Bristol Myers Squibb'
#Immunology #Autoimmunity #CARTcells
https://www.ft.com/content/a974f4c1-bb8a-4a1b-9d88-a2cf14be5c6e

2024-07-13 11:45:13

“I know you’re trying to skirt around it,” says Benjamín Labatut when I put to him that his books concern people of unworldly intelligence working on problems that are maximally deep, “but the best way to sum it up is: ‘Why am I interested in mad scientists?’” Fair play. There’s no getting away from it: that’s exactly what his richly satisfying, deeply researched books are about.'
https://www.theguardian.com/books/article/2024/jul/13/people-say-my-book-gave-them-a-panic-attack-when-we-cease-to-understand-the-world-author-benjamin-labatut

2024-07-13 10:41:06

'Male and female humans are born with the same number of cardiomyocytes — the predominant cardiac cell type by mass; however, in adulthood, males have a significantly smaller proportion of cardiomyocytes. This is thought to be due to testosterone-induced apoptosis in the male heart, although differences in cardiomyocyte-regenerative capacity may also contribute.'
https://www.jci.org/articles/view/180074

2024-07-13 07:34:52

“Since anyone can subscribe to obtain such a ‘verified’ status, it negatively affects users’ ability to make free and informed decisions about the authenticity of the accounts and the content they interact with,” said regulators in Brussels.'
https://www.ft.com/content/9419e3b1-60ab-4bcb-a1ea-30cca911667a

2024-07-13 07:25:25

- reply

@npub1j5u…rg9f They payed Mackenzie millions to come up with this brilliant innovation (really).

2024-07-13 07:24:45

'Criminals also commonly paste fraudulent Ozempic labels onto insulin pens, said Mr. Safdar. After fake Ozempic in Austria landed people in the hospital last fall, health officials said they suspected it was actually insulin. Reuters reported in January that three people in the United States developed hypoglycemia, or dangerously low blood sugar, after taking suspected counterfeit Ozempic.'
https://www.nytimes.com/2024/07/12/well/ozempic-fake-counterfeit-drugs.html

2024-07-13 07:19:19

'If the current forecasts are an indication, municipalities will be grappling with these questions for some time. Another two dozen daily temperature records could be broken to begin the weekend. The extreme heat will push into the Midwest and the East by early next week, with heat indexes as high as 110 expected in the Philadelphia area and in the low 100s in New York.'
https://www.nytimes.com/2024/07/12/us/us-heat-wave-weather-forecast.html

2024-07-12 14:22:24

'The tool — a type of ‘base editor’ — modified the target gene in more than 90% of an Escherichia coli colony inside the mouse gut. “We were dreaming of being able to do that,” says Xavier Duportet, a synthetic biologist who co-founded Eligo Bioscience, a biotechnology company in Paris. The findings were published today in Nature.'
https://www.nature.com/articles/d41586-024-02238-3

2024-07-12 12:27:13

'The findings suggest that i) the Romans most likely discovered the islands around the 1st century BCE; ii) Berber groups from western North Africa first set foot on one of the islands closest to the African mainland sometime between the 1st and 3rd centuries CE; iii) Roman and Berber societies did not live simultaneously in the Canary Islands; and iv) the Berber people rapidly spread throughout the archipelago.'
https://www.pnas.org/doi/10.1073/pnas.2302924121

2024-07-12 09:36:04

'These studies have helped to answer “some of the questions that were precipitated by the FDA announcement,” Maus said. They still have not found definitive evidence that CAR-T therapy has directly caused new cancers, she said, and scientists continue to suspect that such an event would be extremely rare.'
#Immunology #Immunotherapy #CARTcells
https://www.statnews.com/2024/07/12/cancer-car-t-therapy-fda-secondary-cancers/?utm_campaign=rss

2024-07-12 09:15:01

Lisbon (Biblioteca de Alcantara)
https://media.social.qoto.org/media_attachments/files/112/772/755/820/590/989/original/c2dff77d6324bb4d.png

2024-07-12 09:01:59

'All in all, polygenism has been hugely influential in American scientific racism and its fallout. Indeed, you cannot fully understand American racism without understanding polygenism and its history. So how did polygenism first gain traction? And how did it become a mainstream view among the American scientific establishment?'
https://aeon.co/essays/modern-racism-rests-on-scientific-theories-from-the-19th-century

2024-07-12 08:57:42

'Studies suggest that the virus is spreading between cows through contaminated milking equipment, rather than airborne particles. The biggest risk is that it could evolve to infect mammals more effectively, including through the respiratory system, which would make it more difficult to contain. Given the close and regular contact that cows have with people, airborne transmission could spark a pandemic'
https://www.nature.com/articles/d41586-024-02237-4

2024-07-12 08:55:54

'Pfizer is planning to test a daily weight-loss pill in mid-stage trials later this year, as the struggling pharmaceutical group pins its hope on the experimental drug as its route into a market projected to be worth more than $130bn a year.'
https://www.ft.com/content/865f8432-6c88-40ca-a48e-06b30a81f176

2024-07-12 06:08:39

'The activation of the STING–MAPK–CREB signaling pathway induces the expression of many cytokine genes, including interleukin-2 (IL-2) and transforming growth factor-beta 2 (TGF-β2), to promote the Treg differentiation.'
https://www.pnas.org/doi/10.1073/pnas.2320709121

2024-07-11 13:33:53

Behold!
'The mayor wheeled the new NYC Bin down Gracie Mansion’s driveway and, with his characteristic swagger, demonstrated how the innovative new technology works: you open the lid and you put the rubbish in. It’s highly intuitive technology.'
https://www.theguardian.com/us-news/article/2024/jul/10/new-york-city-trash-cans-nyc-bin-eric-adams?CMP=Share_AndroidApp_Other

2024-07-11 11:27:27

'However, we found through a chance encounter that some unscrupulous actors have added extra references, invisible in the text but present in the articles' metadata, when they submitted the articles to scientific databases. The result? Citation counts for certain researchers or journals have skyrocketed, even though these references were not cited by the authors in their articles.'
https://phys.org/news/2024-07-scientific-fraud-uncovering.html

2024-07-11 11:25:39

'At his rehabilitation medicine practice in Illinois, Dr. Azlan Tariq typically spent seven hours a week fighting with insurance companies reluctant to pay for his patients’ treatments.
He often lost.'
https://www.nytimes.com/2024/07/10/health/doctors-insurers-artificial-intelligence.html

2024-07-11 10:19:27

'The results of these efforts were extraordinary, however. The images revealed jumping spiders, weevils, dragonfly nymphs, and myriad other arthropods in exquisite detail, from an unprecedentedly personal perspective.'
https://publicdomainreview.org/collection/book-of-monsters/
https://media.social.qoto.org/media_attachments/files/112/767/347/001/770/955/original/0de9799a12c80d69.png

2024-07-11 10:14:22

'Here, we developed a multi-tumor mouse model system to track hundreds of expanding and contracting CD8+ T cell clones over multiple timepoints in tumors of the same individual. Through coupling of clonal expansion dynamics and single-cell RNA/TCR-seq data, we identified a transcriptomic signature in PD-1+Ly108+ precursor exhausted cells that strongly predicts rates of intratumoral clone expansion in mice and humans.'
#Preprint #Immunology
https://www.biorxiv.org/content/10.1101/2024.07.05.601623v1

2024-07-11 10:08:10

'A play, Kyoto — which had its world premiere last month at the Royal Shakespeare Company’s Swan Theatre in Stratford-upon-Avon, UK — attempts to cast a fresh light on climate narratives by focusing on the negotiations of the Kyoto Protocol. This international treaty, signed on 11 December 1997 in Kyoto, Japan, was the first to commit countries to reduce their greenhouse-gas emissions to mitigate climate change.'
https://www.nature.com/articles/d41586-024-02251-6

2024-07-10 10:18:39

'We observed that multiple aspects of science identity were positively impacted by participation in the mentorship program, including mentees’ sense of belonging to the community of scientists (80%), feeling that their identity and background are welcomed in their academic program (88%), feeling like they belong in science (90%), their perception of the daily work of scientists (83%), sense of value as a scientist because of their identity and background (71%), and certainty of their place in science (68%).'
https://www.biorxiv.org/content/10.1101/2024.04.02.587784v1

2024-07-10 07:53:16

'Medical experts in Japan are to add a “most severe” category to the current heatstroke index, amid warnings that the extreme heat is straining medical services and causing damage to public health comparable to that in a “natural disaster”.'
https://www.theguardian.com/world/article/2024/jul/10/japan-adds-most-severe-category-to-its-heatstroke-index-amid-deadly-summer

2024-07-10 07:51:11

'É impensável alguém ocupar um lugar de topo na hierarquia do Estado durante seis anos sem nunca ter dado uma entrevista. A ideia de que isso é possível resulta de uma outra, mais profunda e perigosa: a de que um PGR não está sujeito ao escrutínio público.'
https://expresso.pt/opiniao/2024-07-10-lucilia-gago-uma-corporacao-quevive-de-si-por-si-e-para-si-39ea6fef

2024-07-10 07:42:40

'As part of its latest fundraise, the venture firm raised $2.6bn for its eighth fund and $1bn to deploy across parallel funds, which will invest in specific sectors, such as certain diagnostics or therapeutics. Flagship is also likely to raise extra money for its eighth fund later this year, helping it meet a target of $3bn for the investment vehicle.'
https://www.ft.com/content/2e530667-49e0-4c8b-895b-d02c7984a6e4

2024-07-10 07:17:31

'Keytruda has beaten Roche’s TIGIT drug candidate at the first interim analysis of a phase 2/3 lung cancer trial, prompting the Swiss drugmaker to stop the study and consider changes to the broader program.
(...)
Roche found the survival data favored the Keytruda regimen at the first interim analysis. The assessment of progression-free survival (PFS) generated a hazard ratio of 1.27.'
#Immunotherapy #Immunology
https://www.fiercebiotech.com/biotech/roche-stops-pivotal-tigit-trial-after-keytruda-lands-knockout-blow-first-attempt

2024-07-10 06:52:30

'Agassiz and others used polygenism to boost scientific support for slavery, to the extent that, as the anthropologist Charles Loring Brace points out in ‘Race’ is a Four-Letter Word (2004), their advocacy became a contributing factor to the American Civil War.'
https://aeon.co/essays/modern-racism-rests-on-scientific-theories-from-the-19th-century

2024-07-10 06:50:40

'The first patient to receive a kidney from a genetically engineered pig was Richard Slayman, 62, who had the procedure in March at Mass General Brigham in Boston. Though he was well enough to be discharged two weeks after the surgery, he, like Ms. Pisano, suffered from complex medical problems and died within two months.'
https://www.nytimes.com/2024/07/09/health/kidney-transplant-pisano.html

2024-07-09 15:17:35

'On 21 June, Barcelona mayor Jaume Collboni announced plans to ban short term rentals in the city starting in November 2028. The decision is designed to solve what Collboni described as "Barcelona's biggest problem" – the housing crisis that has seen residents and workers priced out of the market – by returning the 10,000 apartments currently listed as short-term rentals on Airbnb and other platforms into the housing market.'
https://www.bbc.com/travel/article/20240701-what-does-a-world-without-airbnb-look-like

2024-07-09 15:07:01

'He (Pascal) is separated from us by the Enlightenment, which was as awed by his scientific talent as it was ashamed of his religious intensity, and by the Romantics, who held him up as a paragon of the sickly genius, the divine, suffering prodigy.'
https://literaryreview.co.uk/algebra-other-idle-pursuits

2024-07-08 09:43:55

'Many of us associate Covid with respiratory issues. But some people who get sick with the virus never experience a sore throat, coughing or body aches, said Dr. Peter Chin-Hong, an infectious disease specialist at the University of California, San Francisco. Certain people end up feeling more like they have food poisoning than anything else.'
https://www.nytimes.com/2024/07/05/well/covid-symptoms-stomach-pain-diarrhea.html

2024-07-08 09:36:26

Greetings Vienna
https://media.social.qoto.org/media_attachments/files/112/750/191/055/511/387/original/a1bc54ae0ffffe44.jpeg

2024-07-08 06:31:14

“The plea deal . . . unfairly makes concessions to Boeing that other criminal defendants would never receive,” the families argued in a court filing. “As a result, the generous plea agreement rests on deceptive and offensive premises.”
https://www.ft.com/content/b0864de7-aaa4-4c9a-b992-698aafdd8048

2024-07-08 06:16:55

'This first-hand exposure to the ravages of dementia turned out to be key in shaping Evans-Newton’s professional life: as chief executive of Alzheimer’s Research UK, she now leads the biggest funder in Europe of research into the causes of, and potential treatments for, dementia.'
https://www.ft.com/content/a0035c2a-92ca-44c7-b055-435e0f4734d2

2024-07-08 06:12:54

'Taxonomy, the science of naming and classifying organisms, is the foundation for conserving disappearing plants and animals. Yet the field — often viewed as an archaic, dusty tradition that harks back to intrepid 19th-century botanists describing the plants of newly colonized lands — is dying.'
https://www.nytimes.com/2024/07/07/opinion/to-save-life-on-earth-bring-back-taxonomy.html

2024-07-08 05:38:34

'The world has baked for 12 consecutive months in temperatures 1.5C (2.7F) greater than their average before the fossil fuel era, new data shows.
Temperatures between July 2023 and June 2024 were the highest on record, scientists found, creating a year-long stretch in which the Earth was 1.64C hotter than in preindustrial times.'
https://www.theguardian.com/environment/article/2024/jul/08/temperatures-1-point-5c-above-pre-industrial-era-average-for-12-months-data-shows

2024-07-08 05:26:23

'Here, we present proof-of-concept that a logistic regression model is capable of differentiating between three paradigmatic lymphomas—nodular lymphocyte predominant B cell lymphomas (NLPBL), diffuse large B cell lymphoma (DLBCL), and chronic lymphocytic leukemia (CLL).'
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011570

2024-07-07 18:57:23

'When Steve was around 10, a doctor informed him and my parents that he most likely had a genetic disorder called Marfan syndrome. Suddenly, the idea of physical normalcy became deeply and personally relevant. My brother’s life story had converged with the story of genetic medicine.'
https://theamericanscholar.org/imperfecta-2/

2024-07-07 09:28:01

'An entire set of Hiroshige’s colorful depictions of his native city was bound into a book, donated to the Brooklyn Museum and left in storage for 40 years before being unbound in the 1970s. Because it was probably intended especially for such a collection, this particular set was also a kind of luxury edition, made with extra care and details, like the use of reflective metallic dust, that ordinary consumer-grade prints, for all their intricacy, didn’t have.'
https://www.nytimes.com/2024/07/04/arts/design/hiroshige-art-brooklyn-museum-woodblock.html

2024-07-07 08:26:55

'Myeloid-derived suppressor cells (MDSCs) could differentiate into functional osteoclasts. Moreover, B cells, especially switched memory B cells, could promote the osteoclastogenic potential of MDSCs in rheumatoid arthritis'
https://onlinelibrary.wiley.com/doi/full/10.1002/eji.202350823