'Here, we developed a multi-tumor mouse model system to track hundreds of expanding and contracting CD8+ T cell clones over multiple timepoints in tumors of the same individual. Through coupling of clonal expansion dynamics and single-cell RNA/TCR-seq data, we identified a transcriptomic signature in PD-1+Ly108+ precursor exhausted cells that strongly predicts rates of intratumoral clone expansion in mice and humans.'
#Preprint #Immunology
https://www.biorxiv.org/content/10.1101/2024.07.05.601623v1
Thiago Carvalho /
npub1xa…czham
2024-07-11 10:14:22
Author Public Key
npub1xakev87fgm9edqu6f5jhszwunekjxl3dpnq4sxvm3nzu2ace8xnqyczhamPublished at
2024-07-11 10:14:22Event JSON
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