Leszek

Father.
Computational biologist.
Working on #RNA modifications.
Passionate about #nature, #music and IT.

#selfhosting most of my own services.

searchable

website: https://wasi.ovh/yachay/
codeberg: https://codeberg.org/lpryszcz/
ORCID: https://orcid.org/0000-0003-0790-067X

Public Key

npub1evcm80g373hmze9av74jrudf5ftx2ewk62gf6uzrwm5n4p9rg8ssv2kl7l

NIP-05 Address

lpryszcz_at_genomic.social@momostr.pink

Profile Code

nprofile1qqsvkvdnh5glgma3vj7k02ep7x56y4n9vhtd9yyawpphd6f6sj35rcgpz3mhxue69uhhyetvv9ujuerpd46hxtnfduqs6amnwvaz7tmwdaejumr0ds52kqxz

Publishing to

relay.damus.io

nos.lol

Author Public Key

npub1evcm80g373hmze9av74jrudf5ftx2ewk62gf6uzrwm5n4p9rg8ssv2kl7l

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Last Notes

2026-09-10 13:34:53 UTC

I'd like to prepare more #vegetarian and #vegan food, especially from locally sourced products.
Could you recommend some #books , ideally #recipes for #mediterranean climate
#bookstodon #ClimateCrisis

2026-09-02 09:53:32 UTC

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"Global heating will reach at least 1.8C under even the most optimistic future, well beyond the Paris agreement goal of 1.5C, according to a UN report
... best hope for humanity to limit damage was to adopt an “overshoot, peak and decline” pathway that required immediate and sustained greenhouse gas emissions cuts combined with steps to remove carbon dioxide from the atmosphere."
https://www.theguardian.com/environment/2026/sep/02/global-heating-warming-1-8c-best-case-scenario-un-united-nations-environment-programme-report

2026-08-05 14:07:14 UTC

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“Silicon Valley oligarchs are really vulnerable right now,” says Durán. “People don’t like them. People are starting to rise up against data centres and this vision of an AI apocalypse that kills all the jobs and potentially kills all of humanity. You’re scaring the hell out of people and now they don’t like you. Into that could step a politician to take advantage of that trend and come up with a message that speaks to the concerns of people and against the dark fantasies of the oligarchs.”

2026-08-05 14:04:48 UTC

"Palantir has an estimated $13.7bn in US government contracts; last year, its stock price rose more than 90% in six months. Andreessen is backing dozens of defence companies scooping up government contracts and recently joined the Pentagon’s advisory board. Last week, Musk’s SpaceX received a $1.6bn contract to supply rockets to the US Space Force – on the same day he pledged at least $100m to help Republicans in November’s midterm elections."
https://www.theguardian.com/lifeandstyle/2026/aug/05/journalist-taking-on-tech-fascists-silicon-valley

2026-07-12 09:56:59 UTC

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thanks for sharing. A lot of meaning gets lost in writing, therefore it's super important to try to look at every response and comment in the nicest possible interpretation. It's very hard though...
And I know, there are some duchebags out there, but most of us are really caring and willing to help one another. I think we miscommunicate and/or misinterpret the message more often than express true hostility. That's why it's important to take a deep breath before replying :)

2026-07-01 13:29:13 UTC

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you can enable it in Settings > security & privacy > private space
More details
https://discuss.grapheneos.org/d/16670-private-space-on-android-15-grapheneos

2026-07-01 12:28:38 UTC

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great move, definitely get familiar with private space. I keep all intrusive apps there (installed via Google play) and enable it only if needed.
My main profile is free of Google :)))
It's really boring phone, I get notifications mostly when private space is active...

2026-06-28 19:46:07 UTC

"Spotify's effective payout averages roughly $0.003 to $0.005 per stream... By contrast, Bandcamp pays artists roughly 82% of each sale. A direct $10 album sale can exceed revenue from thousands of streams. Buying music or books directly from artists, whether physical or DRM-free digital, is one of the most direct ways to support them."
Artists are likely better off when you #buy one album (and #pirate the rest) than from your #streaming #subscription!
#music #capitalism
https://dervis.de/physical/

2026-06-28 13:15:19 UTC

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"Is it best to have no alcohol?
Not necessarily. “There’s a danger the advice can be counterproductive,” said Maughan. Having the odd pint of weak beer can help with hydration, but if people are warned off all alcohol, they may not replace it with water, juice or other drinks.
"
Oh come on @npub13yw…wwpf , it's like worrying people that are told not to smoke will stop breathing...🤦

2026-05-30 12:56:39 UTC

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I went to sleep hoping I will find and answer. Frankly I don't know... I'm not trained in computational sciences, switched to bioinformatics from biology. So I can only share from my experience. There is definitely some personal preference. I tried Perl, Python, R, Java, C, C++, Ruby, Julia, Go, Lisp and Rust. I hated them all expect Python, because only Python feels "natural" to me. But I know some of my friends feel like that about C++, Java, R, Rust or Lisp 🫣

2026-05-29 19:52:38 UTC

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it's not only about style, it's also about community and environment. Starting in bioinformatics and machine learning will be easier with Python than any other language, because of rich ecosystem. Languages themselve evolve, but entire world around then as well. So what works well today, may be not optimal in a couple of years...

2026-04-06 14:21:47 UTC

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thanks, it works great indeed! Added @npub12zq…fc5r and #molly repositories manually. It would be great to provide more popular repositories preconfigured like #neostore does

2026-04-02 13:58:08 UTC

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akurat używam Molly bez blob. Na głównym profilu mam tylko aplikacje z @npub1mtr…trt0 , ale przez #neostore, działa lepiej niż oryginalna apka
W przestrzeni prywatnej mam cały syf z Google Play, aktywuje je tylko raz na kilka dni :)

2026-04-02 11:45:25 UTC

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w Hiszpanii można kupić nowy Pixel 10a poniżej 400€ (w lutym wyprzedawali 9a za 309€). Od ub roku używam @npub1kwa…e0nj na 9a, jest rewelacyjny! Z istotnych aplikacji nie działa tylko Google Pay, a alternatywy (np Curve) nie udało mi się aktywować ani razu.
Podejrzewam, że Pixel 7-8a będzie działał podobnie, nie różnią się znacznie sprzętowo od kilku lat...
Polecam!
https://www.simyo.es/simyo/telefonia-movil/sistema/android/

2026-03-26 20:51:54 UTC

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There is a very real risk that this conflict will end with Iran as the de facto master of the Strait of Hormuz and the Persian Gulf, having demonstrated that no one can stop them from determining by force which ships pass and which ships cannot. That would, in fact, be a significant strategic victory for Iran and an enormous strategic defeat for the United States.

2026-03-26 20:29:16 UTC

"As you can tell, I think this was a bad gamble: it was very unlikely to succeed but instead always very likely to result in a significantly worse strategic situation for the United States, but only after it killed thousands of people unnecessarily. If you do a war where thousands of people die and billions of dollars are spent only to end up back where you started that is losing; if you end up worse than where you started, well, that is worse."
https://acoup.blog/2026/03/25/miscellanea-the-war-in-iran/

2025-12-11 15:06:49 UTC

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I registered a .ovh domain (2€ with 3€ annual renewal).
You can get free subdomain ie check @npub129e…3cyx
As long as you have public IP there is no need to use virtual server, you could be serving everything from your home / office.

2025-11-02 07:05:11 UTC

Probably most of you are aware how toxic profit driven social media can be, here another experiment confirming this
https://www.abc.net.au/news/2025-11-02/social-media-ban-algorithm-phone-addiction-instagram-x-tiktok-/105844066

2025-10-15 18:52:28 UTC

Guido van Rossum: I am definitely not looking forward to an AI-driven future. I’m not worried about AI wanting to kill us all, but I see too many _people_ without ethics or morals getting enabled to do much more damage to society with less effort...
I hope that Python’s legacy will reflect its spirit of grassroots and worldwide collaboration based on equity and respect rather than power and money, and of enabling “the little guy” to code up dream projects.
https://www.odbms.org/blog/2025/10/beyond-the-ai-hype-guido-van-rossum-on-pythons-philosophy-simplicity-and-the-future-of-programming/

2025-10-10 03:32:57 UTC

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Hi @npub1xzt…tyk0 , #selfhosting could be a move in the right direction for you. I started managing my own servers over 10 years ago, locally, from my home, later VPS and finally again from my home. Eventually I moved toward @npub129e…3cyx - it simplifies a lot of things! I documented some my experiences at https://wasi.ovh
Start small: setup file/photo sync (@npub1rk6…hv4q), calendars and contacts and gradually start adding data from old backups once you feel comfortable.
Have fun and good luck :)

2025-08-17 21:23:46 UTC

Visited #Bordeaux with my family. The Miroir d'eau, or pool for poor as I like to call it, is a fantastic place for days like today, when the heat is hard to bear...
#silentSunday
https://cdn.masto.host/genomicsocial/media_attachments/files/115/046/208/263/874/143/original/180e8c19330bd684.jpg

2025-07-19 11:09:20 UTC

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dzięki, profili jeszcze nie miałem okazji wypróbować. Taka dygresja, zakup telefonu #Pixel odwlekałem ponad rok, bo przecież to bez sensu, kupować telefon wyprodukowany przez #google , żeby ulepszyć swoją prywatność. Niestety żaden inny producent nie zapewnia wsparcia/funkcji w #Android potrzebnych wymaganych przez #grapheneos . Więc w końcu się zdecydowałem na #pixel i to była dobra decyzja !

2025-07-19 08:43:32 UTC

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sama instalacja jest prosta: potrzebny jest laptop (Linux lub Windows) z przeglądarką chrome/chromium i kabel USB. I po 15-30 minutach system jest gotowy do pracy:)
Uwielbiam mnogość opcji konfiguracji #grapheneos i prywatną przestrzeń, w której trzymam wszystkie aplikacje, które korzystają z #google #play. Te aplikacje mogą być uruchomione tylko po odblokowaniu prywatnej przestrzeni i nie mają dostępu do danych/kontaktów/zasobów z głównej przestrzeni. Super pomysł!

2025-07-19 08:35:07 UTC

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używam @npub1kwa…e0nj od czerwca i póki co nie mam żadnych problemów. Jedną aplikację, która nie działa jest #google #wallet, z którego i tak lepiej nie korzystać ze względu na prywatność.
Z ważnych aplikacji działa m.in. #moje #ing i #mObywatel oraz wszystkie inne, które używałem wcześniej na oficjalnym Android

2025-06-26 14:13:45 UTC

And it happened, I'm trying @npub1kwa…e0nj on my new mobile.
So far very good! Installation was smooth, configuration took a bit of time, but added #privacy, #security and control is likely worth it.
The only thing that isn't working is #google #wallet, I guess I'll have to learn to live without it :)
#android

2025-02-26 09:39:55 UTC

Shamelessly sharing our latest publication: De novo basecalling of #RNA #modifications at single molecule and nucleotide resolution
#nanopore
https://link.springer.com/epdf/10.1186/s13059-025-03498-6?sharing_token=IytKQ2p-kKbfSMJeCUsTt2_BpE1tBhCbnbw3BuzI2ROlz0B3e9LQUoHA9qh6NODgonYuX1G1GMfsxEe_sTuS_e_GRybSYX9mxrEoeASxC5RIlpmlV0mD6YesQ7BOjIbYdaxcUKYz3q8l2T2_bvSlO8Tykxj3ICWTyjPsKAmQ36s%3D

2025-02-08 14:13:01 UTC

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you can find nearly all missing .gov websites archived by replacing .gov with .govwayback.com
For example this website still lives here
https://www.nasa.govwayback.com/universe/nasa-intern-found-hope-in-the-moon-2

2025-02-04 17:42:42 UTC

Thank you all for making @npub163h…mv0n and #fediverse open, accessible, friendly, ad and bullshit free.
I'm so happy there are still usable corners in otherwise dysfunctional internet mess
https://archive.fo/PbkAY

2025-02-02 17:49:51 UTC

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another reminder how little control of the data you have in VPS . #onsite #hosting may be viable alternative for smaller projects. What to do with larger ones?

2025-01-27 08:03:03 UTC

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maybe it's time to return to dummy phones, dummy as used for calling and sending text messages instead of mobile computers aimed at everything?

2025-01-16 08:59:56 UTC

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already running in my website. and I'm being quite offensive :)
you can grab random articles from wikipedia using `w3m -t 1 -s https://simple.wikipedia.org/wiki/Special:Random > corpus.txt`, strip header/footer and feed them sequentially to #nepenthes
https://zadzmo.org/code/nepenthes/

2025-01-04 18:07:35 UTC

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oh my, you need to give birth to get 12 months of health coverage? In Spain you get free healthcare (free as paid by the state, which means taxpayers) once you have permanent residence address. Your family or working status doesn't matter. Every resident deserves a public healthcare.

2024-12-29 04:46:24 UTC

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it's a mediawiki page unfortunately without a possibility to create a new account without invitation. You can see who was editing the page same and possibly find this people
https://www.encyklopediafantastyki.pl/index.php?title=Greg_Egan&action=history

2024-12-10 10:09:37 UTC

Instead of building new highways and parkings, maybe it's time to redesign our cities so we can just walk around?
https://www.theguardian.com/lifeandstyle/2024/dec/10/the-five-minute-city-inside-denmarks-revolutionary-neighbourhood

2024-11-28 10:46:02 UTC

@npub19rt…adh9 creates Mastodon accounts for everyone at vivaldi.social . Once you log in, they send you a few welcome tips about fediverse. I find it really nice for newcomers! Thank you :)

2024-11-24 18:28:50 UTC

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thank you! We've been to Leon, but definitely going again to see the surroundings :)))

2024-11-24 18:01:51 UTC

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hi, could you please tag where the photo was taken?

2024-10-25 07:41:33 UTC

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Discovering #phallusThursday made my Friday morning!