Comte de Sats Germain on Nostr: I'm a bit unsure about how it works, but my current best stab at it is that kidneys ...

I'm a bit unsure about how it works, but my current best stab at it is that kidneys filter out what's perceived to be an excess of a mineral, and everything hits the gut first. The gut can handle "bioavailable " minerals easier because gut bacteria prefer to eat stuff that's already bound into some longer molecule - the gut then puts the nutrients into the bloodstream, where either your body uses them or the kidneys filter out excess. Magnesium is a double hit on the kidneys because first it causes a rush of water to the gut, which stresses kidneys (the body has a hierarchy of water priority, and kidneys are higher than gut in priority) and second because the nephrons in the kidneys are so small that mineral crystals can be a tight fit - protein even more so - and that's actually good because nephrons are the filter. But you increase the damage to the nephron's this way. In healthy kidneys its no problem - they're healing at a faster rate than the damage - but the more damaged they are, the more damage they'll take. So, I think more bioavailable magnesium would be better, but if the gut is damaged, then it'll leak more into the bloodstream, where it won't matter if its bioavailable or not.

I'm not 100% about all this.