Wtf
https://abstracts.eurospe.org/hrp/0097/hrp0097p2-91
> We present a case of peripheral precocious puberty in a 3-year-old girl due to inadvertent exposure to an estradiol gel used by her father as gender affirming hormone therapy (GAHT).
> Case description: A 3-year-old girl was referred to our pediatric outpatient clinic with breast development and vaginal discharge over a period of 6 months. The GAHT of her transgender father was estradiol spray 6.12 mg applied to both forearms daily. After 6 months this was changed to estradiol gel 3.75 mg daily for 7 months. The gel was manually applied to the chest, abdomen, shoulders, and thighs. The father reported skin to skin contact on a daily basis. A physical examination of the girl revealed a Tanner stage III for breast and Tanner stage I for pubic hair development. Height was 108.1 cm (+3,2 SD), weight 19.7 kg (+0,54 SD) and bone age advanced to 6.9 years (Greulich and Pyle). Pelvic ultrasound demonstrated increased size for age of both uterus and endometrium corresponding to Tanner stage III-IV. Estradiol was 0.04 nmol/l and GnRH stimulation test revealed a peak LH of 2.0 IU/l with a LH/FSH ratio of 0.77. MRI of the pituitary gland was normal. These clinical, radiologic and laboratory findings were consistent with a diagnosis of peripheral precocious puberty due to exogenous estradiol. The hormone therapy of the father was changed from a gel to a transdermal patch, and the girl experienced regression of breast development, normalization of growth velocity, pelvic ultrasound and GnRH stimulation test.
Yuchen Pei
npub1lr…y6wd6
2025-07-18 23:50:52 UTC
Author Public Key
npub1lrjcrnkmd035mvhzl98qyep73v7zvx5mxmpx7m8m467df545vyysry6wd6Seen on
wss://relay.momostr.pinkPublished at
2025-07-18 23:50:52 UTCEvent JSON
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"content": "Wtf\n\nhttps://abstracts.eurospe.org/hrp/0097/hrp0097p2-91\n\n\u003e We present a case of peripheral precocious puberty in a 3-year-old girl due to inadvertent exposure to an estradiol gel used by her father as gender affirming hormone therapy (GAHT).\n\n\u003e Case description: A 3-year-old girl was referred to our pediatric outpatient clinic with breast development and vaginal discharge over a period of 6 months. The GAHT of her transgender father was estradiol spray 6.12 mg applied to both forearms daily. After 6 months this was changed to estradiol gel 3.75 mg daily for 7 months. The gel was manually applied to the chest, abdomen, shoulders, and thighs. The father reported skin to skin contact on a daily basis. A physical examination of the girl revealed a Tanner stage III for breast and Tanner stage I for pubic hair development. Height was 108.1 cm (+3,2 SD), weight 19.7 kg (+0,54 SD) and bone age advanced to 6.9 years (Greulich and Pyle). Pelvic ultrasound demonstrated increased size for age of both uterus and endometrium corresponding to Tanner stage III-IV. Estradiol was 0.04 nmol/l and GnRH stimulation test revealed a peak LH of 2.0 IU/l with a LH/FSH ratio of 0.77. MRI of the pituitary gland was normal. These clinical, radiologic and laboratory findings were consistent with a diagnosis of peripheral precocious puberty due to exogenous estradiol. The hormone therapy of the father was changed from a gel to a transdermal patch, and the girl experienced regression of breast development, normalization of growth velocity, pelvic ultrasound and GnRH stimulation test.",
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