nprofile1qy2hwumn8ghj7un9d3shjtnyd968gmewwp6kyqpqgyygqy9s7phexfkpc680ncea7n6ft9nmdzl9rkm8wn7p4lhralwq9ppajl (nprofile…pajl) What languages are you targeting? It is worth bearing in mind that French is the only modern European language in which both æ and œ occur, but even there use of æ is rare.
In Mediaeval and Early Modern Latin texts both occur frequently, but these days ae and oe are strongly preferred.
To my knowledge, very few orthographies anywhere use both these letters.* So the possibility of confuseability of the italic forms is less of a practical concern than one might think simply from looking at the shapes.
* nprofile1qy2hwumn8ghj7un9d3shjtnyd968gmewwp6kyqpqu40fymdgg69tqc9phhv79zck0ldfkhf086aueeq3c5qfjyqjzuxqdfy5sf (nprofile…y5sf) can probably identify those that do.