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Becomes extremely problematic when you gain enough expertise in methodology to realize that wide swaths of everything in science is methodologically dead on arrival.
There have been some useful articles written to highlight this, standard methodology, and clearly (intentionally) broken studies.
https://pmc.ncbi.nlm.nih.gov/articles/PMC61047/
https://www.bmj.com/content/363/bmj.k5094
nprofile1qy2hwumn8ghj7un9d3shjtnyd968gmewwp6kyqpq37ruf9lq7ue3fh35p5sltcpsrsvkdfk6vuxtmaglzqd024t3w7ms93nmr0 (nprofile…nmr0)