MCDuncanLab on Nostr: In the epiblast, lumen formation initiates from unique organelle called the apicosome ...

In the epiblast, lumen formation initiates from unique organelle called the apicosome that contains apical proteins like podocalyxin and a primary cilium. But how does the apicosomes form? We knew that the apicosome was closely associated with various types of endosomes and also with lysosomes, and that it contains endocytosed material. Here, we explored the involvement of endosomes and lysosomes in the formation of the apicosome in a cellular model of early development. 3/