Imma push back on this way hard.
Cryogenic methane is a truly lousy solvent. There is a VERY short list of organic molecules that will dissolve in it and let you shuttle energy-carrying molecules from one place to another.
I challenge anyone to build up a biochemical cascade using ONLY cyclopropane and butane.
(And I'm not even mentioning synthesis of A+B-->AB where AB is so insoluble it gloms itself to the enzyme active site - catalytic turnover of one.)