MCDuncanLab on Nostr: And this is where it intersects with another line of research. In the early 2000s, ...

And this is where it intersects with another line of research. In the early 2000s, Kathleen Sakamoto, Craig Crews and Ray Deshaies described the first attempt to hijack the cells quality control system to target a protein they chose.

The process worked in principle, but they needed to find a better way to bring the quality control system to the protein they wanted to destroy.
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https://pmc.ncbi.nlm.nih.gov/articles/PMC37474/