nprofile1qy2hwumn8ghj7un9d3shjtnddaehgu3wwp6kyqpqzmjzu82r647tatk0790numnqngvffk03njys33ldhgssx9m6euyqzjmugr (nprofile…mugr) Gnus’ nnagent is really a cache, so expiring old cached entries periodically is fine (everything remains on your IMAP/NNTP server).
Do you use offlineimap together with mu4e? And public-inbox (?) to get a Maildir local copy of mailing lists?