2026-04-26T20:57:44Z https://yabu.me Steve Gisselbrecht https://yabu.me/npub1lv6k3gy8n6t3mvm20xu32d5at4cvlkwjrcvmw0p6vlytjrus4v4qca0q9p https://media.mas.to/accounts/avatars/109/363/238/536/197/967/original/6f731b09b2138c55.jpg https://media.mas.to/accounts/avatars/109/363/238/536/197/967/original/6f731b09b2138c55.jpg https://yabu.me/nevent1qqs0pfwnhzp045h4l4zmh08487tza4uta2agqsyphl4ya75pzaek0qgzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5c9nx6v In reply to <a href='/nevent1qqsy80ekyjvefy74nkdxts7cekwajpcrjyln3s40kmgqsqrvjn28rsgtpmppu'>nevent1q…mppu</a><br/>_________________________<br/><br/>The two week desk reject maybe pisses me off more than anything else. 2026-04-04T20:17:11Z https://yabu.me/nevent1qqsd254kyteg384v39fsfaussqtzve8c6twtgla9xsc79fk8k4xu0jszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5h9apzc In reply to <a href='/nevent1qqs25h82n6yl3jx96ls076uf2acxq3rp6qcp37sftt6qtn2qn4t3nuqawnaym'>nevent1q…naym</a><br/>_________________________<br/><br/>At a party at our house once, a friend&#39;s daughter remarked to him how cool it was that our stereo had a thing on top that made it look like it was playing a vinyl record, and he blew her mind by explaining to her that in fact it was playing a vinyl record and that&#39;s where the music they were hearing was coming from. 2026-04-01T21:51:16Z https://yabu.me/nevent1qqs0g7t7axaxe4mje06gzat6sgeclnc4f0rf3fxucl6hqacz8z8rluqzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5syld27 If you feel somehow tempted to participate in April Fool&#39;s Day this year, you may subtly work a fish, or a fish reference, into a post. That&#39;s it.<br/><br/><a href="https://en.wikipedia.org/wiki/April_Fools%27_Day#Italy,_France,_Belgium,_and_French-speaking_areas">https://en.wikipedia.org/wiki/April_Fools%27_Day#Italy,_France,_Belgium,_and_French-speaking_areas</a> 2026-03-31T22:14:22Z https://yabu.me/nevent1qqsx5qdst7rgrad7gge09j8rredrtepddeqy2y3zxa8y6gf8wv4aj7szyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5dk9tc8 In reply to <a href='/nevent1qqsyldn2qfujqqn7cxy2g49aqtd0upzdan3tywp8qqym64gph9r08sszcgu9t'>nevent1q…gu9t</a><br/>_________________________<br/><br/>The Culture novels are so, so, SO good. Seeing someone say &#34;Oh yeah I&#39;ve been meaning to read those&#34; makes me wanna scream RUN TO THE BOOKSTORE they are amazing and wonderful. 2026-03-28T19:36:12Z https://yabu.me/nevent1qqspav33fjhmem8wqk6weagwvcfeu8hgvkyq75wtzvguq34uu2cpl7czyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5lp08nw In reply to <a href='/nevent1qqsdz6g8vvl2ehe0yf23ym2wkzd9jwtxnsv0pmm8lu9fcmwnk65a60g5neg05'>nevent1q…eg05</a><br/>_________________________<br/><br/>Japanese Kitkats go HARD. 2026-03-11T16:03:51Z https://yabu.me/nevent1qqsx3xxrgzqxghp5c4hj8g3q50kagz82qvj2xkgqu5v0tnj9hhjhdtqzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5nvy3aj In reply to <a href='/nevent1qqsqwghyxh777nxmkadfzaqp2n9p40nwah7nw56hskr0pr3nlamngmsyfjrp7'>nevent1q…jrp7</a><br/>_________________________<br/><br/>WE ARE LOVING THIS 2026-03-02T00:11:53Z https://yabu.me/nevent1qqszd4m39gggp976szvmkks4v5su6fklvlp8jyn5h6l6lch3uafj96czyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5z9lyha In reply to <a href='/nevent1qqszfqxywdtljzf4sx3n86qyuvttqfrtsgyjnyt7v0a5f7yystmu0csn334q4'>nevent1q…34q4</a><br/>_________________________<br/><br/>As long as there were sport peppers. 2026-02-26T18:28:23Z https://yabu.me/nevent1qqsdyfgjah77z457l3x2wz0c28pcnp4rj3kaqwn5puywwjdzz4n6n5szyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5ta6kgq RE: <a href="https://social.vivaldi.net/@xtaldave/116104608789438895">https://social.vivaldi.net/@xtaldave/116104608789438895</a><br/><br/>Aw. This was the cell bio professor who was lecturing and told us about some protein XYZ1, also called DEF5, also known as UVW3, etc., then turned from the board and deadpan said, &#34;Scientists would rather use each other&#39;s toothbrushes than use each other&#39;s nomenclature.&#34;<blockquote class="border-l-05rem border-l-strongpink border-solid"><div class="-ml-4 bg-gradient-to-r from-gray-100 dark:from-zinc-800 to-transparent mr-0 mt-0 mb-4 pl-4 pr-2 py-2">quoting <br/><span itemprop="mentions" itemscope itemtype="https://schema.org/Article"><a itemprop="url" href="/note18kct4gkvq7n0hkq2sukgshfr00x9v4rn6fjtcumuvvwkc8xpvvxqrxe3df" class="bg-lavender dark:prose:text-neutral-50 dark:text-neutral-50 dark:bg-garnet px-1">note18kc…e3df</a></span><br/> </div> Very sad. Excellent scientist, but also a warm and friendly human being.<br/><br/>Richard Hynes, a pioneer in the biology of cellular adhesion, dies at 81 | MIT News | Massachusetts Institute of Technology<br/><a href="https://news.mit.edu/2026/richard-hynes-dies-0123">https://news.mit.edu/2026/richard-hynes-dies-0123</a> </blockquote> 2026-02-21T06:57:09Z https://yabu.me/nevent1qqs9vklkw9xnq4n3gn2shar6azr6gn6rxu2cwr8ygkhsl3w09nnqtgszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5alhf4g My Jesse Jackson memory:<br/><br/>Back in the 1900s, I would occasionally actually watch the Democratic Convention on TV. And, perhaps unsurprisingly, Jesse Jackson was a featured speaker.<br/><br/>It was a barnburner. The bit I clearly remember is that he contrasted the amount spent per student in Compton schools with the amount spent per prisoner in LA County jails, concluding with, &#34;For these kids, JAIL is a STEP UP! JAIL is a STEP UP!&#34;<br/><br/>The speech went on and on and left the audience enraptured. (…) 2026-02-17T20:17:54Z https://yabu.me/nevent1qqszxjkst5t4x630v2ppz44k2jw4mfap7renqtc759uf2sjl39p96qszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5p2zgqu In reply to <a href='/nevent1qqs22kkspt5l72qksesszwz3anaau56fcz469zd6q2j5f6t7qs4ch3s77lrlz'>nevent1q…lrlz</a><br/>_________________________<br/><br/>What a badass name for a building! I&#39;m sorry I didn&#39;t know about it when I visited Pittsburgh as a tourist! 2026-02-16T21:39:14Z https://yabu.me/nevent1qqsdy3hrh9wejxx7y9juj2a8mt2gae88zwy2ategzh90hxmdts57rmczyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5fh28z6 I filed my taxes last weekend and there&#39;s a spot on the US federal tax return for &#34;Occupation&#34; and friends, I still legitimately feel a thrill putting &#34;Scientist&#34; in that box. Every. Single. Time.<br/><br/>There are things that are shitty about it, it&#39;s a job like any job, sometimes you don&#39;t wanna, and then there&#39;s now (!), but if you asked me when I was FIVE what I wanted to be when I grew up, that was the answer. I&#39;m living the dream. It&#39;s a stress dream right now, yes, but it&#39;s the dream. 2026-02-16T03:55:58Z https://yabu.me/nevent1qqs9l0zltevwvswd0szk3mstj9sjmsvx9pe9x0arfxvf24l63u4psqszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5nps4s7 I baked.<br/> <img src="https://media.mas.to/media_attachments/files/116/041/917/490/759/505/original/0491b47a5fb8c1f2.jpeg"> <br/> 2026-02-09T17:47:51Z https://yabu.me/nevent1qqsxsytjuv9up336p34vr4fzlakksg0esrs08hhen0ju4ary459azhgzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5zm2ckr In reply to <a href='/nevent1qqsd6a7uehwzs6nc5l54mq7levskt2atf852qu6v3y7j3t6hfyuwh3sa9hcsr'>nevent1q…hcsr</a><br/>_________________________<br/><br/>Aw, honey, I&#39;m so sorry. 2026-02-03T04:42:30Z https://yabu.me/nevent1qqsw8rarmyf73329ldc694ufwk6pk0qhf9qnkvdprz6z05lc37x6ysszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j574y3cs Once again had a really intense week and made … a drop of clear liquid. It looks like water. (It&#39;s mostly water.)<br/><br/>It&#39;s about one one-hundredth of a teaspoon.<br/><br/>I&#39;m gonna send it away and we&#39;re gonna pay someone like $3,000 and weeks from now they&#39;ll send us gigabytes of data about that drop of liquid, and then I will find out if any of this worked or not.<br/><br/>My job is weird. 2026-01-30T00:18:40Z https://yabu.me/nevent1qqs287pvpkhn5gpyptvlhvjhvgdpvm8lwl0vvvl2uw80vwn4xrgcl5gzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5rhjt23 In reply to <a href='/nevent1qqsfdwtlpk4xetwh4why9d0y66q7w7n99lp68fgea008ef2vauep2ksr3d096'>nevent1q…d096</a><br/>_________________________<br/><br/>More? I got lots of these. 2026-01-26T06:58:47Z https://yabu.me/nevent1qqsfdwtlpk4xetwh4why9d0y66q7w7n99lp68fgea008ef2vauep2kszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5wflgxj In reply to <a href='/nevent1qqsv4w7gqwk25jww53xhaz2f3xx07c6uz73cj84ulx6ry0datf60ync2t0z9w'>nevent1q…0z9w</a><br/>_________________________<br/><br/>… and then the very tips are formed from little membrane sacs inside the cells (the technical term is &#34;vesicles&#34;) that line up and fuse together to make incredibly fine tubes that fill with air. Oxygen-starved tissues send out a signal that nearby tracheal cells respond to by growing more of these tube-tips in their direction. 2026-01-26T06:58:30Z https://yabu.me/nevent1qqsv4w7gqwk25jww53xhaz2f3xx07c6uz73cj84ulx6ry0datf60ynczyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j585r6hk In reply to <a href='/nevent1qqsp32824uggz2y3uvp0756pdgh2dk7hnssy7n5k5dydvl7jvpdhnvccdqy59'>nevent1q…qy59</a><br/>_________________________<br/><br/>Oh man I am an Insect Professional.<br/><br/>I don&#39;t know their level, though. Do they know that insects don&#39;t have lungs? They don&#39;t use their &#34;blood&#34; for gas exchange (which is why it&#39;s not technically referred to as blood but we say &#34;hemolymph&#34;), but instead the tracheal system completely penetrates the body, bringing oxygen directly to all the tissues with a system of microscopic air-filled tubes. The main branches are a couple cells around, the finer branches just one cell around … 2026-01-26T06:56:42Z https://yabu.me/nevent1qqsvwhzly3qph5gxs9k4mlj6rauwm6s2sxa0zc7jqxmt6rpsj3kueaszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j57853kt In reply to <a href='/nevent1qqsznjnkfx8tdu4lqf58k4g6xfrqm56ykv7pcdp4hsl7m8gw8zlpjrc7qnx7d'>nevent1q…nx7d</a><br/>_________________________<br/><br/>Technically marjoram is just a specific cultivar of oregano! But they are plenty different, with marjoram being (to my nose) milder; I would use marjoram in a salad and oregano in cooked things. 2026-01-22T22:19:10Z https://yabu.me/nevent1qqs9g8v07dd9ctcmwu77dhyl0ky94yrgvelc2mc5ctyedvl2g0ndepszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5hy47gj It is HIGHLY characteristic of me that I have two different sourdough starters in my fridge.<br/><br/>(It is much less characteristic of me that they are named. I was an extremely literal child—my teddy bear was called Teddy Bear until it got too beat up to repair and had to be retired to a shelf, after which it was called Old Teddy Bear and its replacement New Teddy Bear—but for historical reasons, the classic starter became named Johnny, and so obviously the buckwheat starter is Bucky.) 2026-01-18T01:54:50Z https://yabu.me/nevent1qqspd30vh6jye6w7lqqqv8zdfn7r7r30lwv4rrfrnxz5lpmkq3jjy8czyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5ar5mew In reply to <a href='/nevent1qqsd2szhvzwsdmfq4jd5c9ss2zuz7qhut38ptxm23edy42ucfee947cc6wu68'>nevent1q…wu68</a><br/>_________________________<br/><br/>They need to have the blood in units so that they know how much they&#39;re giving a patient. Often when a patient is getting a transfusion, it&#39;s an emergency, so they want to grab &#34;one unit&#34; and not have to think about how much is in the container. (They already have to think about blood type.)<br/><br/>I donate platelets, and they will take a single, double, or triple depending on the donor&#39;s platelet count and how well they tolerate the procedure. (I can only do singles but I go often.) 2026-01-14T01:07:14Z https://yabu.me/nevent1qqs867qfm0pydqs0zv078w9caasf6nnc2t2fjyjlnp9rrsywvhsv0fqzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5vkaazc In reply to <a href='/nevent1qqsp6ynexk9nlyppzadmymz9unjy5ggadvgqmx56re8g8djeu2u2q8csx8f0s'>nevent1q…8f0s</a><br/>_________________________<br/><br/>I am That Friend to a LOT of my friends!<br/><br/>I work with maggots. You&#39;re not gonna gross me out. 2026-01-12T17:40:34Z https://yabu.me/nevent1qqsfzz5qxvxwq4t95hz9g3ksq42wvc3twxzyhvapccxempxaxnkvz6czyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j52umt20 In reply to <a href='/nevent1qqsqmtt8c26qy60vz6kklv05yavprqhv0addyvz8wnrplx8kyvamdzsgfyyn7'>nevent1q…yyn7</a><br/>_________________________<br/><br/>Absolutely would. 2025-12-31T03:01:45Z https://yabu.me/nevent1qqsrkq6cdql5qe099knqjr3qnpxst9lgzjk9gfu8ver7rvnx229ky6gzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5tmfgz6 It is the Thursdayest of Tuesdays. 2025-12-30T20:50:33Z https://yabu.me/nevent1qqsfkzdvlzvqfrwlrqkmuqsdhue9w5cp0mak9w798k29d0hdczspghczyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5m7wzc2 In your 40s, you learn not to trust joints. You shoulder hurts for days because you &#34;slept funny,&#34; your knees hurt forever because bipedalism only evolved recently and is frankly still in beta, etc.<br/><br/>In your 50s, you learn that hands and feet are ENTIRELY MADE OF JOINTS. 2025-12-21T22:46:39Z https://yabu.me/nevent1qqsg9cj6qkg5fpgmsx6jfeqw5n053dkq9dlfehnavz9qgcnsn6tdvjczyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5r7ljez We love a fractal vegetable.<br/> <img src="https://media.mas.to/media_attachments/files/115/596/530/837/767/388/original/455d9f4442dd8025.jpeg"> <br/> 2025-11-23T02:00:38Z https://yabu.me/nevent1qqsxs2duc9sly66474xg83pfvnlmetgk256kvcej7huq3v7jljkd2sczyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5rxpadn In reply to <a href='/nevent1qqs90m5ay0ynqmn65sc2n9pmquekc2yjeugl709l5uqvvnpwn4wjpxgwryj6p'>nevent1q…yj6p</a><br/>_________________________<br/><br/>OMG<br/><br/>Fuck that. I can&#39;t believe that. Doesn&#39;t he even know??? 2025-11-07T21:47:00Z https://yabu.me/nevent1qqsz64fakvkn0gzps94af75hlh4ftnsxjpmj8srw646nzglzcw2832czyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5uw3h2r In reply to <a href='/nevent1qqs0nztew3v2hmgq4rn8zznjyq86s56rg6emk8hevrcjy4q8gde5pdg59psre'>nevent1q…psre</a><br/>_________________________<br/><br/>Aw, thank you.<br/><br/>Part of the issue is I can&#39;t think of anything *I* can do. 2025-10-31T19:24:24Z https://yabu.me/nevent1qqsrlpc28c70epgssv76nhw6as5h0qmxp4mf0v829quxvga0cvr0w8szyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j53k7ua6 In reply to <a href='/nevent1qqsgmzlaswsczrdl5287w3qyqu99d0yz00859gwn85cexzqdsraqrmqu53hzt'>nevent1q…3hzt</a><br/>_________________________<br/><br/>P.s.: If you imagine for one moment that I don&#39;t feel guilty complaining about how the current political situation affects my JOB while people are literally being bundled from their homes at gunpoint by the secret police, you clearly don&#39;t know me. I can find a way to feel personally bad about most anything. 2025-10-31T18:13:02Z https://yabu.me/nevent1qqsgmzlaswsczrdl5287w3qyqu99d0yz00859gwn85cexzqdsraqrmqzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5dy9rad In reply to <a href='/nevent1qqs0teu50f4fqc3s5nr36pe9mk3wjgc66v9284hgdk6d3v9axepa00cwdvapv'>nevent1q…vapv</a><br/>_________________________<br/><br/>And somehow I&#39;m supposed to get motivated to keep going to work, writing grant proposals that literally no one is even going to read, much less fund, reading papers to try to design experiments that I&#39;ll never be allowed to do, and maintaining strains that I can&#39;t afford to use for anything.<br/><br/>It&#39;s just a shitty, shitty time and I&#39;m not really okay. 2025-10-31T17:39:18Z https://yabu.me/nevent1qqs0teu50f4fqc3s5nr36pe9mk3wjgc66v9284hgdk6d3v9axepa00czyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5948xk6 In reply to <a href='/nevent1qqsvxaqwg5a340fz624fytcevs66k9qf9sx6rz6j445ke32nt3ktxacln2e9z'>nevent1q…2e9z</a><br/>_________________________<br/><br/>He has been there for a dozen years. He has a small child, and a condo with a mortgage. He is a great guy and I like working with him. He is a brilliant scientist and just published a really great paper in Nature Structural and Molecular Biology. And he&#39;s out in 3 months, unless we get some money from somewhere, which how the fuck is that supposed to happen?<br/><br/>He&#39;s also the last one getting paid other than my boss and me, so I feel like next on the block. … 2025-10-31T17:37:19Z https://yabu.me/nevent1qqsvxaqwg5a340fz624fytcevs66k9qf9sx6rz6j445ke32nt3ktxaczyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j584c075 In reply to <a href='/nevent1qqsx4gl2290qw7mm6mylk5j2t0nemcumqykhcdpq26mpqdpkh5xaa3ck2k67e'>nevent1q…k67e</a><br/>_________________________<br/><br/>Which they&#39;re not, because the government is shut down, so the NIH &#34;study sections&#34; that review them are not meeting. All of which means that our lab is running out of money. I literally can&#39;t do the experiments that I want (and have prepared) to do because I can&#39;t order reagents.<br/><br/>And then, on Monday, I learned that my favorite coworker is basically getting laid off. … 2025-10-31T17:35:39Z https://yabu.me/nevent1qqsx4gl2290qw7mm6mylk5j2t0nemcumqykhcdpq26mpqdpkh5xaa3czyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5nkzcr2 In reply to <a href='/nevent1qqspe7jt6zvdzfkhyr2qs99tpa8pe4dcvz48490vee02d3zxt2xmqgg32fwye'>nevent1q…fwye</a><br/>_________________________<br/><br/>Recently it&#39;s more the foredrop, though. My big grant ran out and the renewal was scored quite well the LAST time the Republicans fucked up government funding, so even though it got quite a good score (11th percentile, where lower is better, which would normally be an obvious fund), they wound up not funding it and giving us a 1-year extension. Which ran out a couple months ago.<br/><br/>Meanwhile, current paylines are supposedly at like 5th percentile, even if grants were getting reviewed. … 2025-10-31T17:34:29Z https://yabu.me/nevent1qqspe7jt6zvdzfkhyr2qs99tpa8pe4dcvz48490vee02d3zxt2xmqggzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j577jule In reply to <a href='/nevent1qqsdprd973ld22q3dp6gsmr06gpfkjcauhvalhfvugxmfnrjh0dxptgxw8cu0'>nevent1q…8cu0</a><br/>_________________________<br/><br/>The idea being that knowing more basics about how biology works puts us in a better position to understand and, eventually, intervene in human health issues. This has sort of been the consensus in the US since about the end of WWII.<br/><br/>So obviously our political system is broken. Obviously. That consensus is gone. The NIH is being brutally slashed. All of that is a stressful backdrop to my day-to-day life. (…) 2025-10-31T17:31:00Z https://yabu.me/nevent1qqsdprd973ld22q3dp6gsmr06gpfkjcauhvalhfvugxmfnrjh0dxptgzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j52r9aa0 Okay, I&#39;ve been kind of cryptically whiny this week. That&#39;s mostly been compartmentalization: the things bothering me are things I mostly can&#39;t do anything about, and they bother me a lot, so I try not to think about them.<br/><br/>As you probably know if you&#39;re reading this because I NEVER SHUT UP ABOUT IT, I am professionally a scientist. I work for someone with a reasonably big name in our field, at a fancy institution, trying to figure stuff out with NIH money. (…) 2025-10-31T17:29:19Z https://yabu.me/nevent1qqstm6ctcskg5f3tlga23xvz7ewt0j9gtjg0qk34jyw8073rtqt8zfgzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5fhg4vd Autumn in New England is autumning and this is part of my yard today.<br/> <img src="https://media.mas.to/media_attachments/files/115/453/414/457/924/202/original/9968c06499edf62b.jpeg"> <br/> 2025-10-28T19:23:45Z https://yabu.me/nevent1qqsy3zkvxs7xqtzn66sjq9ru7yv598gu5q3k085tr6qrk89x6capr5czyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5yedg5x In reply to <a href='/nevent1qqsz6e6utt56hs9ryu7hhr2phxuxdth4x6zaaeapdsa78h72w5ah9tg8qh784'>nevent1q…h784</a><br/>_________________________<br/><br/>It&#39;s no surprise when she had such a terrific mom. 2025-10-24T03:04:49Z https://yabu.me/nevent1qqs83vrkpje49n2zw77gkrfhdua88gf8xd60pg2h7awg7q6an24e6zgzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5cgxehj In reply to <a href='/nevent1qqsqydntlu2w8gwlchc0739h0a4cekdsclek34hwt39h8qa9z76t8xg5ergyl'>nevent1q…rgyl</a><br/>_________________________<br/><br/>OH HELL YES 2025-10-17T22:39:46Z https://yabu.me/nevent1qqsdxm027cnd3hn2sm8gl2d35eupdmgp9zf9vs7x2txnrsnzz3hc9yqzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5ee2e00 Please remember that &#34;Red Tape&#34; is why there&#39;s no sawdust in your bread and the nearest river has not actually caught on fire lately. 2025-10-17T18:23:43Z https://yabu.me/nevent1qqsdguwpwsqx4w4n2vskj7lf32wz8azaljtqu4juatm426jnpdguwwczyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5cuq3yy In reply to <a href='/nevent1qqsvgepuk9scv7kk6wvv93t24mg38fpr7svx8zwphy5a5ug0qxvw49gnmx4et'>nevent1q…x4et</a><br/>_________________________<br/><br/>I know y&#39;all love the updates (as do I) and not only is the ribcage nearly done but she&#39;s thinking about the logistics of taking him to the No Kings protest in Chicago because she is that cool.<br/> <img src="https://media.mas.to/media_attachments/files/115/373/685/851/458/662/original/460ed6b1a6bf7c6c.jpg"> <br/> <img src="https://media.mas.to/media_attachments/files/115/373/686/499/799/036/original/f73a84d9894b57cb.jpg"> <br/> 2025-10-14T17:27:24Z https://yabu.me/nevent1qqsthxdkqhz9vqm84u2ww9g2xkyrg2ejng2r2c2ukdxwtdsxy7ydvpszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j59rk8lk A note on the word &#34;biscuit.&#34;<br/><br/>The US use of the word is etymologically incorrect. AND SO IS THE BRITISH ONE! It&#39;s from roots that mean &#34;twice baked,&#34; and if the Italians could be bothered to even notice our food kerfuffles at all, they&#39;d be over there giving us side eye because biscotti actually ARE. &#34;Ship&#39;s biscuit&#34; was a form of hardtack, US biscuits and UK biscuits are both named that because they reminded someone slightly of actual biscuit, stop fronting like anyone is &#34;right&#34; here. 2025-10-03T04:08:48Z https://yabu.me/nevent1qqs8a62xcgf3058ctfxq4lkqfkkljn9e5fgz3x74t28jvx0mwzfr6uszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5tdxtyl In reply to <a href='/nevent1qqsz8zhfx0qrdhhc48v26qxa2vs9290zjgwrcrkkssl8p4etyre5d0q9m7syk'>nevent1q…7syk</a><br/>_________________________<br/><br/>Eventually, a bigger mutation that removed an entire broken gene, or several of them, made a version of our ancestor with a little less DNA to copy each time a cell divided. And it could spend that tiny bit of extra energy on reproducing faster. And it did. Still no balancing cost, because it had to eat anyway. Before you know it (on evolutionary timescales), the whole species needed niacin in its diet.<br/><br/>Each vitamin is a separate version of that same story. (8/8) 2025-09-21T00:15:23Z https://yabu.me/nevent1qqsz8zhfx0qrdhhc48v26qxa2vs9290zjgwrcrkkssl8p4etyre5d0qzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j529zw5u In reply to <a href='/nevent1qqs9smd8svfqn4nshmnycw5wy7fzq8m7eqy8pja2sj5zz24jnglaxhswrghav'>nevent1q…ghav</a><br/>_________________________<br/><br/>We eat living things, and as mentioned, every cell in every one of them contains these chemicals.<br/><br/>So some ancestor of ours had a mutation that broke a gene required to make niacin, but they and their children were fine, because they got all the niacin they needed just by eating enough fruit and leaves and meat and seeds to survive. And without that selection pressure, additional mutations accumulated in the genes of that pathway. (7/n) 2025-09-21T00:12:53Z https://yabu.me/nevent1qqs9smd8svfqn4nshmnycw5wy7fzq8m7eqy8pja2sj5zz24jnglaxhszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j58d4n8x In reply to <a href='/nevent1qqswec25h37urdt8wlvcrukczf6y265nt009qel4cf9kzzmee0cyv9cg5qeds'>nevent1q…qeds</a><br/>_________________________<br/><br/>But the fact that they look quite different from other things we normally make, chemically, means that it&#39;s kind of a pig to make them. It takes a lot of energy and a whole complicated system, with multiple genes that need to be copied and maintained and transmitted, just to make each one. All of which increases the energy required to grow and reproduce.<br/><br/>And we eat, is the thing. (6/n) 2025-09-21T00:10:31Z https://yabu.me/nevent1qqswec25h37urdt8wlvcrukczf6y265nt009qel4cf9kzzmee0cyv9czyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5vecxzm In reply to <a href='/nevent1qqs9gqh6cmhxzyvxhdulx2f78q2nts0gw4epcv7amex7ekj0gjs7dfs746myl'>nevent1q…6myl</a><br/>_________________________<br/><br/>Niacin and riboflavin both have these complicated ring systems with at least one nitrogen and lots of delocalized double bonds, so they&#39;re pretty flexible about how they configure their electrons. This makes them very useful for redox reactions, and they are used to shuttle electrons around by, as far as we can tell, absolutely every living cell that has ever done biochemistry. For a lot of cells, the ability to make these bad boys is completely necessary for life. (5/n) 2025-09-21T00:08:04Z https://yabu.me/nevent1qqs9gqh6cmhxzyvxhdulx2f78q2nts0gw4epcv7amex7ekj0gjs7dfszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5ekeyjy In reply to <a href='/nevent1qqsqy9ywjtdvdnszjclcd92uqt5zwmvn30uwh82tv3hv490je6met3svzcugz'>nevent1q…cugz</a><br/>_________________________<br/><br/>Now, a common feature of your proteins and nucleic acids is that they&#39;re pretty stable, as these things go. Particularly to oxidation and reduction. And what &#34;stable&#34; means in this regard is that it takes (or releases, depending) a lot of energy to oxidize or reduce them. This is great when you need them to stick around. But if you want to catalyze oxidation/reduction (&#34;redox&#34;) reactions, you need a chemical that&#39;s pretty close to equally happy in either oxidized or reduced state. (4/n) 2025-09-21T00:04:33Z https://yabu.me/nevent1qqsqy9ywjtdvdnszjclcd92uqt5zwmvn30uwh82tv3hv490je6met3szyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5phqj6g In reply to <a href='/nevent1qqsdw0zj36hmhlkrmcza7u3jdk6fjm0ulph37gcgvqy9tvfjgqy509qaf93w3'>nevent1q…93w3</a><br/>_________________________<br/><br/>Vitamins tend to have chemical properties that make them good for catalyzing reactions that the &#34;normal&#34; chemicals available to your cells—the RNA and the various amino acid side chains found in all your proteins—aren&#39;t good at.<br/><br/>A great example is niacin and riboflavin. These are used by every cell in your body for reactions where other chemicals are oxidized (= have electrons removed) or reduced (= have electrons added). Oxidizing sugar and reducing oxygen, say, to harvest energy. (3/n) 2025-09-21T00:02:11Z https://yabu.me/nevent1qqsdw0zj36hmhlkrmcza7u3jdk6fjm0ulph37gcgvqy9tvfjgqy509qzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5mg9n7r In reply to <a href='/nevent1qqsg4jrhj6txq46ts3f9qsgnutwjecu44ng82ueu3qkf7kqagu2vuks0c6aa9'>nevent1q…6aa9</a><br/>_________________________<br/><br/>They mostly have chemical properties that enable them to be used as catalysts. By definition, a catalyst is something that participates in a reaction but is returned unchanged at the end, so you reuse them and only need enough to top up what you lose of your supplies to entropy. This distinguishes them from, say, carbohydrates, where the whole point is to burn them for energy or break them up for raw materials. (2/n) 2025-09-20T23:59:05Z https://yabu.me/nevent1qqsg4jrhj6txq46ts3f9qsgnutwjecu44ng82ueu3qkf7kqagu2vukszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5msqnrc This evening&#39;s biochemistry info dump (because that&#39;s a thing I do) is &#34;Vitamins: why even are they?&#34;<br/><br/>Vitamins are, of course, chemicals (or &#34;small molecules&#34; because when you&#39;re used to thinking about DNA and proteins, something with 20 carbons and 3 or 4 fused rings is a small molecule) that you need to have in your diet, in relatively small amounts, or you will get sick and eventually die. That&#39;s the &#34;vita&#34; part of the name; they were named when they figured out they were vital. (1/n) 2025-09-20T23:56:33Z https://yabu.me/nevent1qqsq2cr3re3tzjcmzal5zu8udrmyw833dajqjr0mjdfeu2pw2q5zukczyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j530s5xc I may have mentioned this here before, but our common fruit flies are really yeast flies. They&#39;d starve if they tried to eat only sterile fruit. The reason they&#39;re so interested in fruit is that that&#39;s where yeast grows, in nature. Rotting fruit is mostly rotting with various yeast species. Lay your eggs on fresh fruit because that&#39;s where rotting fruit comes from.<br/><br/>Consequently, when I feed the sourdough, the fruit flies around our compost collection bowl become EXTREMELY interested! 2025-09-15T23:01:02Z https://yabu.me/nevent1qqsvuyaj97yqdh6ugfsxj88443vt04wmv6m3l3q2rvxlke3zsu8ad8gzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5ulgdyt Just replying about the importance of reporting harrassment in a black person&#39;s mentions was enough to get me two different racist trolls responding, obviously with homophobic abuse because of course.<br/><br/>If you have enjoyed the privilege of thinking that the fediverse does not have a racism problem because we&#39;re all so great here, stop that right now. 2025-09-06T22:04:52Z https://yabu.me/nevent1qqsvgepuk9scv7kk6wvv93t24mg38fpr7svx8zwphy5a5ug0qxvw49gzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5hqnpcm In reply to <a href='/nevent1qqsf3n8mac5w9yfljs7js7pfkcwf6qvlhrr3lse4gaj5k4dy0qw7t6genj47g'>nevent1q…j47g</a><br/>_________________________<br/><br/>The &#39;S&#39; word (&#34;September&#34;) has her really pushing to have it ready to display in mid-October and I am so impressed.<br/> <img src="https://media.mas.to/media_attachments/files/115/158/866/610/380/944/original/d2f31c874f46ce5e.jpg"> <br/> <img src="https://media.mas.to/media_attachments/files/115/158/867/562/830/656/original/55104278a3ed411e.jpg"> <br/> 2025-09-06T18:57:00Z https://yabu.me/nevent1qqsqf8l2l9yx6rkz34nl2s2xxsmsdch06ummfygkcyu6slxw7hfe7xczyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5pkadcn In reply to <a href='/nevent1qqsz5c6p34c5ufh52s9h6ra794v3pgxggw30jrytyec5fwe2scmphasl5sxtj'>nevent1q…sxtj</a><br/>_________________________<br/><br/>The reporting is key, and showing us this so that we can also report it.<br/><br/>Although when I tried to go to their account to do so, their instance is already blocked by mas.to. 2025-09-06T18:50:37Z https://yabu.me/nevent1qqsf3n8mac5w9yfljs7js7pfkcwf6qvlhrr3lse4gaj5k4dy0qw7t6gzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5mn7dgq In reply to <a href='/nevent1qqsy9rexnkn7sdy5zza54u2fp330mjnp06wf2rezgqs6ueanplz9fdsdmrj05'>nevent1q…rj05</a><br/>_________________________<br/><br/>Oh man she is flying through August. She&#39;s back to thinking it might be ready by Halloween!<br/><br/>She said something about &#34;new colors&#34; to tie things together but, again, I&#39;m colorblind, so some of those details are lost on me.<br/> <img src="https://media.mas.to/media_attachments/files/115/079/034/204/505/475/original/d976cfc0bef5a950.jpg"> <br/> <img src="https://media.mas.to/media_attachments/files/115/079/035/103/445/382/original/fed32360bebc22bd.jpg"> <br/> 2025-08-23T16:35:17Z https://yabu.me/nevent1qqsy9rexnkn7sdy5zza54u2fp330mjnp06wf2rezgqs6ueanplz9fdszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5y8724y In reply to <a href='/nevent1qqsvwj50hcetj7q67zpkm456t8ll9et059nv7k3522rs5zym6pztf0cty6fng'>nevent1q…6fng</a><br/>_________________________<br/><br/>HOLY SHIT SHE BEEN BUSY!<br/> <img src="https://media.mas.to/media_attachments/files/115/053/245/735/536/842/original/069a78fa7bbfa04b.jpg"> <br/> 2025-08-19T03:15:47Z https://yabu.me/nevent1qqsvsrq08fr6qr595ek6f68nz5k4zfufln4evj9r4rtvq0gjs47jlrgzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5s20lfj In reply to <a href='/nevent1qqs84lmr72hjeevrqdgqn2p536u4wz3q222gq624jqctl3lhuw7k0vc0rxfxq'>nevent1q…xfxq</a><br/>_________________________<br/><br/>Oh, sure. At MIT we used to say “IHTFP,” which stands for both “I have truly found paradise” and “I hate this fucking place.” 2025-08-16T01:33:05Z https://yabu.me/nevent1qqsz8aqrp820cdx70cge2szsxfpwazlepraxlulm5m2qsfh050zx4wgzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5ka6g0a In reply to <a href='/nevent1qqsw56ftrl9h3nxzv6n3j5ym7ftlkmgusr6z8lcqcyakuy0hhqhg62qws252z'>nevent1q…252z</a><br/>_________________________<br/><br/>I described the love-hate relationship once, the excitement and disappointment, to an undergrad in the lab who was trying to decide on grad school and she said, &#34;Oh, I get it, it&#39;s the bad-boy boyfriend.&#34; 2025-08-16T00:35:50Z https://yabu.me/nevent1qqs26cfgfy7pvrh8dcpap2an4xm0ysve2f2en4pccpx30lavv24enggzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5cxhrdg In reply to <a href='/nevent1qqs82m4zjwynzu6qnxa7tdzu6qa7wd7d8fu66kjr592nmr29gvce54cmw7c8a'>nevent1q…7c8a</a><br/>_________________________<br/><br/>We love science so much. 2025-08-16T00:30:11Z https://yabu.me/nevent1qqsv7ckkhx6vjxwm4deff9mgdmawrzy6cgl9fzztyjndc8zqvdsczdqzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j57cllfy Your occasional reminder that boobytrap spelled backwards is partyboob. 2025-08-14T06:02:59Z https://yabu.me/nevent1qqsvwj50hcetj7q67zpkm456t8ll9et059nv7k3522rs5zym6pztf0czyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5w58z87 In reply to <a href='/nevent1qqsfng9wuu3u8ulycrve2arsf4jdwpx4qx9a2ttckdzpdrz0kqv7jjqy3jwu3'>nevent1q…jwu3</a><br/>_________________________<br/><br/>There begins to be ribcage progress!<br/> <img src="https://media.mas.to/media_attachments/files/115/013/777/326/972/966/original/78f8e55c7fc863be.jpg"> <br/> 2025-08-12T03:59:13Z https://yabu.me/nevent1qqsdm58kz7huufjhxknwc3v4g0vw24ggwhkjpwf3p9djny2h3empt2szyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5fpahgp Did you grow up calling your parents&#39; and older relatives&#39; friends, like, &#34;Aunt Karen&#34; and &#34;Uncle Bob&#34; despite not being formally related?<br/><br/>Obvs explain if so motivated. 2025-08-09T20:47:50Z https://yabu.me/nevent1qqszzjfllylqfhcyrcw9khvfnlnakk3ehen7k5em4a56zttq47lh28gzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5pn6euz In reply to <a href='/nevent1qqsrlmgavvm9t4eu0nsnm7c58wuwlmn2kpw7m6p0zu8fualk04027lsvlxw0u'>nevent1q…xw0u</a><br/>_________________________<br/><br/>Blackberries are juicy, so toss them with a thickener so they don&#39;t sog up the topping. I like arrowroot starch, but flour or cornstarch are also classic. Some people swear by tapioca flour.<br/><br/>Sift in some spices and a little brown sugar while you&#39;re at it?<br/><br/>I like streusel for a crisp: 1 cup flour mixed w/ 2/3 cup light brown sugar, then cut in 1/2 cup salted butter til crumbly. That&#39;s about a 9x13&#34; pan worth. 375°F for 30–40 m, til it&#39;s bubbling and the topping&#39;s browned. 2025-08-06T03:50:51Z https://yabu.me/nevent1qqsgmw0z8g8z4k5nway4ysrgzjc454d9elc34q2hpasr5xdkxfazzcszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j55p55zl The thing that makes me crazy about machine learning in science is that if I said in my Methods section, &#34;I looked at all the data and decided which ones were affected&#34; I&#39;d be crucified in peer review, while if I said, &#34;I trained a recurrent neural network for an unsupervised classification task&#34; it&#39;d be treated as cutting edge science, and the former is the latter with a bigger, better configured network. 2025-08-04T17:49:11Z https://yabu.me/nevent1qqsfng9wuu3u8ulycrve2arsf4jdwpx4qx9a2ttckdzpdrz0kqv7jjqzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5m2mzzy In reply to <a href='/nevent1qqs0a2jhtyxjk4c9z65awcqz8c7dpglv99sxmyswdy6wuznlvnxdfpqggm3lj'>nevent1q…m3lj</a><br/>_________________________<br/><br/>(Anyone doing the math, as she has, will realize, as she has, that the initial estimate of &#34;about a year&#34; was wildly over-optimistic.) 2025-07-27T19:24:31Z https://yabu.me/nevent1qqs0a2jhtyxjk4c9z65awcqz8c7dpglv99sxmyswdy6wuznlvnxdfpqzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5nx8a9z In reply to <a href='/nevent1qqs8vjmghrs5cu9zr4xpaurwnv68pxmh93ysrefnzges5mz6cw6vkcsas9qmm'>nevent1q…9qmm</a><br/>_________________________<br/><br/>Legs are basically done.<br/> <img src="https://media.mas.to/media_attachments/files/114/922/722/286/537/014/original/fc2762ae7305e883.jpg"> <br/> <img src="https://media.mas.to/media_attachments/files/114/922/723/156/484/731/original/f277401f87aaf710.jpg"> <br/> 2025-07-27T02:02:35Z https://yabu.me/nevent1qqspu57qtrsxdsudtujtu0d0cytggc3t9v9x4ysm0wunh6azvuu386czyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5audehc In reply to <a href='/nevent1qqsfa2gdaxmp424rrzre87repkaa49w9fddq0fcdkh9euy668l7x3vq2svpsc'>nevent1q…vpsc</a><br/>_________________________<br/><br/>Another favorite is in:library which is maybe not the most intuitive terminology but searches posts you&#39;ve interacted with, i.e. either boosted or favorited. (Or bookmarked, presumably.) 2025-07-17T16:03:03Z https://yabu.me/nevent1qqsyhujjatq6djrj28jej95wzxgjlly9ykyzgz4jcaltglchmtd567czyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5w2estu How many kinds of vinegar do you currently have? 2025-07-11T15:35:54Z https://yabu.me/nevent1qqsd4u46z8jculksedm8y4ne5pdfe2tcxvrt7gezqvu5s6f202mssdczyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5y4uzst In reply to <a href='/nevent1qqs0mh9ueyta9ut2dyghflf7au8psptvvh97kttx7yy8mup5jsgjfqquhy58n'>nevent1q…y58n</a><br/>_________________________<br/><br/>I&#39;m not really jealous at all and am 100% fine with Christ considering all the same butts I do. He was super-into sharing. 2025-07-10T22:57:12Z https://yabu.me/nevent1qqstwqume2tsd822t84er2la8nntgn2wr8l25t8usga5ny5669law7szyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5zw908u In reply to <a href='/nevent1qqsqzy2f0w7ulkltv8j6ynudrveq7cpmazwqd8gmmvtheyzy858yvkgupehn3'>nevent1q…ehn3</a><br/>_________________________<br/><br/>I have considered butts. I can admit that. 2025-07-10T22:46:25Z https://yabu.me/nevent1qqsgj9vh539ltspac57qh37artqsplpn50d3vcsdqqghz4lyg9hhx5czyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5rahsh0 In reply to <a href='/nevent1qqszdjfmz0sdrwwkgmhlapkzd6su5luzmdvj3mq75axfm5mrjd847dqtxkm4w'>nevent1q…km4w</a><br/>_________________________<br/><br/>When I went to donate and they took my vitals, my resting heart rate was 48, actually below the range that they can take you at. (I had gotten a ride from my husband and was in a pretty relaxed and pleasant mood.) She said, &#34;I need it over 50; you need to be less relaxed.&#34; So I thought briefly about the state of things, and it had increased by 25%. 2025-06-24T21:37:13Z https://yabu.me/nevent1qqszdjfmz0sdrwwkgmhlapkzd6su5luzmdvj3mq75axfm5mrjd847dqzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5pdps8l They made rainbow donor pins when they changed the rules to allow gays to donate platelets and I’m remembering to wear mine for Pride Month!<br/> <img src="https://media.mas.to/media_attachments/files/114/739/403/276/552/988/original/0bf1d449af977f1c.jpeg"> <br/> 2025-06-24T16:59:20Z https://yabu.me/nevent1qqs0mxs3eakch6sqc8cyveypm3h5tgvadcx9gx873wtma64xxzdpm4gzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5aau8vu In reply to <a href='/nevent1qqsgh7ud2uq83jjrcsr8zdw2u0pruhs6mexnnhf559yjh9v842f74asljey3t'>nevent1q…ey3t</a><br/>_________________________<br/><br/>One of my least favorite things about science (AND I HAVE A LIST) is how much work it is to take time off. 2025-05-24T03:24:18Z https://yabu.me/nevent1qqs8vjmghrs5cu9zr4xpaurwnv68pxmh93ysrefnzges5mz6cw6vkcszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j542sj3s In reply to <a href='/nevent1qqs2remxjh62klj04xcmtyvs7ntcm7jjf96vpz78epnya05jwky6kvg4l5x9a'>nevent1q…5x9a</a><br/>_________________________<br/><br/>The left foot has been the focus of recent attention.<br/> <img src="https://media.mas.to/media_attachments/files/114/540/915/347/420/621/original/db19c526f832320b.jpg"> <br/> 2025-05-20T15:43:32Z https://yabu.me/nevent1qqs2remxjh62klj04xcmtyvs7ntcm7jjf96vpz78epnya05jwky6kvgzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5ks8n87 In reply to <a href='/nevent1qqs8hne7uasflf4hfceypjsz6wgnl5rlcwgw3zn4tdv7tm7x5hq4ftcjc86hy'>nevent1q…86hy</a><br/>_________________________<br/><br/>She is sufficiently happy with how the second knee is coming out that she&#39;s now decided to go back and redo the first knee to match. It&#39;s only a few extra hours of work, which, in the context of this project, is trivial.<br/> <img src="https://media.mas.to/media_attachments/files/114/223/979/235/656/889/original/06ee81a7c8f8137b.jpg"> <br/> 2025-03-25T16:22:11Z https://yabu.me/nevent1qqs8hne7uasflf4hfceypjsz6wgnl5rlcwgw3zn4tdv7tm7x5hq4ftczyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5yejms6 I have an acquaintance who is bedazzling her 12-foot skeleton. She started just before last Halloween and expects it to take about a year. She gets high and watches TV and glues rhinestones to it. It relaxes her.<br/><br/>I asked and she said I could share some pictures here, because I just felt like this would be catnip to a certain segment of mastodon.<br/> <img src="https://media.mas.to/media_attachments/files/114/099/584/850/156/486/original/2c17dfbcd6266073.jpg"> <br/> <img src="https://media.mas.to/media_attachments/files/114/122/992/802/665/301/original/f43ccaba6e215f70.jpg"> <br/> <img src="https://media.mas.to/media_attachments/files/114/122/994/810/605/164/original/d7ea3a0136577aa9.jpg"> <br/> 2025-03-03T17:09:18Z https://yabu.me/nevent1qqs9s9ah400s3949q9y766802nxpf27evn5taflvmw8y26ssqhc9hrszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5sruc6m In reply to <a href='/nevent1qqsdc2sgcjqylv5yze4vmsya7ul7n9c70j08fc9pxekl95zsxkl4xycyq8m8n'>nevent1q…8m8n</a><br/>_________________________<br/><br/>If you happen to use firefox, you can preface your search with !w and it will search it in wikipedia automatically. (Sorry if you already know this; I only recently learned it and I love it.) It works for !pubmed and other NCBI (US gov bioinformatics databases) terms too. 2024-12-29T20:04:26Z https://yabu.me/nevent1qqsfescz43yu244ngk5wce038cgd2klarz0d6lu603nev84z36l36hgzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j55x8w7q In reply to <a href='/nevent1qqst7mpk6g6j5hd92r3kdnfrh74gg4me37dgsgjstqkkjx9zetwssls03n486'>nevent1q…n486</a><br/>_________________________<br/><br/>I post this ALL THE TIME but that&#39;s because it&#39;s always relevant.<br/><br/><a href="https://qwantz.com/index.php?comic=2600">https://qwantz.com/index.php?comic=2600</a> 2024-12-19T16:32:27Z https://yabu.me/nevent1qqs8cp0jrx4tdc699y70g8zdmg08yxk556zjqlu7vljd0m4v6hrv4fqzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5aj52h8 In reply to <a href='/nevent1qqs26k45cfz5dndtq9dsruukwaqqv9nsznry2u3mu96c5gvesgcraagvzal34'>nevent1q…al34</a><br/>_________________________<br/><br/>&#34;Hate&#34; is too strong but yeah. 2024-12-17T16:25:29Z https://yabu.me/nevent1qqs2737ky4lgwvnughv60lavd5nyyh7uzgsh5hhdhxtltfj5p80pgjqzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j53u8qu3 In reply to <a href='/nevent1qqsfgtnkvkz99mdy6swnqz72kj0xf5exfprs044a6e3ss5ee9u822ngus4d44'>nevent1q…4d44</a><br/>_________________________<br/><br/>Whole domain is already suspended by my instance.<br/><br/>I LOVE MY INSTANCE ADMIN!!! 2024-12-10T16:19:24Z https://yabu.me/nevent1qqsv486m087v9dslwas0cyhrrauxyserw4d6a0uy8vwx5rndy455mngzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5rrztk8 In reply to <a href='/nevent1qqszqws0myzn850496h2d77ez8tvczdmvr49q0e0h3wll9j5h07xxqs67huve'>nevent1q…huve</a><br/>_________________________<br/><br/>I used to write live music reviews for a local rock zine, and the number of people who were FLABBERGASTED that anyone could not like their band always surprised me. 2024-12-03T19:16:32Z https://yabu.me/nevent1qqsxfweu3ay679kxtqj2da33txxrgdxpfytz5jgfsyt4d5zv59hljrszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5zsj8q0 In reply to <a href='/nevent1qqsvd62smdwxszvekkcve5vt5tw339gcshm7g02d6ghzekyza9uqpqqupn9pe'>nevent1q…n9pe</a><br/>_________________________<br/><br/>Well, we had brought them two pies on Thursday, is the thing. The main question was whether they had finished those and were ready for more. 2024-12-02T23:13:28Z https://yabu.me/nevent1qqs9k8qnllgw0mcjrvt3jms4kvm04f59quzxmjnmf4eha7hrf6sms6szyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5j8z5l6 Text to a friend just now: &#34;You must let me know if the healing power of additional pie is ever what&#39;s needed.&#34; 2024-12-02T18:58:37Z https://yabu.me/nevent1qqsfemf9fgvjnc73pc4fk4pxzjljpaqpzsl7a6xmk5jj73td60urrrqzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j55u8zzd I was thinking, There, I&#39;m done baking for a while, but in fact we&#39;re having bread and soup for dinner tonight and I have a sourdough baguette rising right now. 2024-12-02T01:54:14Z https://yabu.me/nevent1qqsrhd4jqtdc7v2hl9gq7wgaqwe729nrj89s8hsmzxr442y00rklv5qzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j57qpy2d In reply to <a href='/nevent1qqs9cqh5x5svf2p50hx5mqu2ct3thlqqrycexemsauvwekk75vujytgzxjvy8'>nevent1q…jvy8</a><br/>_________________________<br/><br/>Okay I have made 8 different pies today:<br/><br/>• Pecan (plus an extra pecan pie so I&#39;ll have leftovers)<br/>• Chocolate pecan<br/>• Pumpkin<br/>• Maple walnut<br/>• Lattice-top caramel apple<br/>• Diary-free chocolate custard<br/>• Cherry almond<br/>• And a weird experiment that I guess we&#39;ll call &#34;honey walnut raspberry poppyseed&#34;<br/><br/>I love to bake and right now I also kind of love NOT to bake, you know? 2024-11-28T05:54:17Z https://yabu.me/nevent1qqs9cqh5x5svf2p50hx5mqu2ct3thlqqrycexemsauvwekk75vujytgzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j572hl7a In reply to <a href='/nevent1qqszdajvf98xpewejlcmsqaad7emcnqzmevp769m7xy6uwyrr2quwag8s0p2k'>nevent1q…0p2k</a><br/>_________________________<br/><br/>Pies 6 and 7 are in the oven. (All that prep means that once it&#39;s happening, it&#39;s HAPPENING.) 2024-11-28T04:02:32Z https://yabu.me/nevent1qqszdajvf98xpewejlcmsqaad7emcnqzmevp769m7xy6uwyrr2quwagzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5jv58kn In reply to <a href='/nevent1qqsp5z9llxjpdqkr0xz58ecljg0srexs7r03yxt88y3s7hpd44nfjycmekt3p'>nevent1q…kt3p</a><br/>_________________________<br/><br/>After all that time and work I *finally* have a pie in the oven. (But I also have 4 pre-baked crusts and 4 more rolled out and a bunch of fillings half-made so it&#39;s not like I&#39;ve been slacking.) 2024-11-28T01:27:33Z https://yabu.me/nevent1qqsp5z9llxjpdqkr0xz58ecljg0srexs7r03yxt88y3s7hpd44nfjyczyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5nlz9z4 In reply to <a href='/nevent1qqstavxxkeflgxf4juuyh4mx49n79zj72azlmgcvurrs3ywrwg9v7pc8luw20'>nevent1q…uw20</a><br/>_________________________<br/><br/>OKAY WE DOIN&#39; THIS!!! 2024-11-27T21:18:46Z https://yabu.me/nevent1qqstavxxkeflgxf4juuyh4mx49n79zj72azlmgcvurrs3ywrwg9v7pczyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j572zpyy In reply to <a href='/nevent1qqs06r60dcfhjksfgqn2xyram9hulg3zkkxxemr8tdnx95tpckeyq2qmkhc2s'>nevent1q…hc2s</a><br/>_________________________<br/><br/>I&#39;ve also made the crust for the dairy-free pie and started components for two of the fillings. (Three if you count the pumpking roasted this weekend.) That&#39;s plenty for before the actual pie-making day. 2024-11-27T08:37:18Z https://yabu.me/nevent1qqs06r60dcfhjksfgqn2xyram9hulg3zkkxxemr8tdnx95tpckeyq2qzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5rx566c Just made kind of a LOT of pie crust dough. 2024-11-27T06:24:31Z https://yabu.me/nevent1qqsfly8pnysu948wv9e7tr6xpatndd8ppcn2guvlarjsvvxc2s5ghgqzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5l94m7a In reply to <a href='/nevent1qqswtajsmj95vvauratufxt89sqlp4lnnfl7cyjsexgz8mxydradahg3mz2dm'>nevent1q…z2dm</a><br/>_________________________<br/><br/>PIES!<br/>PIES!<br/>PIES! 2024-11-25T16:27:29Z https://yabu.me/nevent1qqsp2pdm5xr2esg0yxwjr9ykar2t7tl6hhzv9llt666f3rr2s4jj65gzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5rq6sc9 When we got the incredible extra-dark Quebec maple syrup, I wondered, if I mix this 1:1 with heavy cream and a pinch of salt and cook it to soft ball, would it be maple fudge?<br/><br/>It not only was, it&#39;s the best maple fudge I&#39;ve ever had.<br/><br/>So then I wondered, if I beat this into softened butter, could it be maple fudge buttercream?<br/><br/>It&#39;s unreal. It&#39;s so good.<br/><br/>So today&#39;s experiment is, if I beat an egg and some flour and baking soda into maple fudge buttercream, can I make maple fudge brownies? 2024-11-24T23:08:58Z https://yabu.me/nevent1qqstk6z8hdp8mhe78jaer3gxva2jcyfvlljep38fc0sve6678dr8s0gzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5uy7eux The longer I study biology, the more I see that our immune systems are perennially poised on a knife edge between &#34;NOT MY PROBLEM&#34; and &#34;BURN IT ALL DOWN&#34; and I&#39;m amazed that any of us ever survives anything ever. 2024-11-23T21:55:37Z https://yabu.me/nevent1qqsvjcaw932aaplfevh4sfm8fn4kmndtas3k0x0nfkgy4cmcyu9l20czyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5q6cdct In reply to <a href='/nevent1qqs80nmdwrkqkypkwmnmxd63nfrcezecuz0w95l64sz355rmdrw3evcp0yv6g'>nevent1q…yv6g</a><br/>_________________________<br/><br/>I thought this was a painting! (I mean, I guess it kind of is. You know what I mean.) 2024-11-18T22:45:02Z https://yabu.me/nevent1qqstgrur5m39k678p6ncxvke9604l4dkgwt82pccduny2q654frsc6qzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j57fjumr In reply to <a href='/nevent1qqsdrtfv0wkeythzturunr268evkulauggr7fs5gj34kcqy559k7wqs4jltlz'>nevent1q…ltlz</a><br/>_________________________<br/><br/>I was fascinated to learn that poison ivy, poison oak, and poison sumac are not particularly related to ivy, oak, or sumac. They are one family that learned the poison trick and then spread into the niches &#34;vine,&#34; &#34;tree,&#34; and &#34;shrub.&#34; Their common names just come from looking vaguely similar to those other plants. 2024-11-15T19:53:18Z https://yabu.me/nevent1qqs2zdu7njt2jeuu9r7u26ustu0pywrxal2tq05txdnej2fknkra08szyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5ypa4gp In reply to <a href='/nevent1qqsresw6kctguqtcn8k9x967dhnl3vxqj4zkcavuk0k5tccxze6642gecry00'>nevent1q…ry00</a><br/>_________________________<br/><br/>Greetings from Canada! 2024-11-11T22:26:27Z https://yabu.me/nevent1qqsresw6kctguqtcn8k9x967dhnl3vxqj4zkcavuk0k5tccxze6642gzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5kn0rcx We’re getting ready to leave the US. <br/><br/>(We’ll *probably* come back?) 2024-11-11T21:37:52Z https://yabu.me/nevent1qqsdqu36x42sm6xv34kzgpqdu50jxrvvxcpdt2s9wg7ttxcmz853gnqzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5lfzhxk In reply to <a href='/nevent1qqsqjuy3rnx77mvc8k480qdn7tel9qvxcx339kh3sth6u608um3wtuqvxfgrc'>nevent1q…fgrc</a><br/>_________________________<br/><br/>Oh man if you candy ginger then you get candied ginger (dip it in bittersweet chocolate, it&#39;s magic) and you get a whole lot of ginger syrup as a side benefit!!! 2024-11-03T00:08:04Z https://yabu.me/nevent1qqsfywt887ljr5kg4ch3x745kn4qvh39cg6fs7nh3ekgwuufrkxddfczyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5kur2p2 In reply to <a href='/nevent1qqs90x0shdfa6ym8ggvh9agzjnl6xgrrw5lsfhg4hz3y8teffkut9fc42m4d9'>nevent1q…m4d9</a><br/>_________________________<br/><br/>A million years ago, my then-boss said, &#34;You&#39;re going to see the Dead in Albany?&#34; I said yes. He said, &#34;Well when you&#39;re tripping, you have to go and see the Egg.&#34;<br/><br/>I accepted this then-impenetrable wisdom and did eventually act on it, and only later did it occur to me that it was at all remarkable that my boss just assumed I would be tripping and we were all fine with that. 2024-10-28T03:13:59Z https://yabu.me/nevent1qqs8q3vhuet2l4zprng9s38t7sa6mcqtseyfq9qdvsfwg0egmjvegkszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5054m4x The Commonwealth should just expel the UK and fully become a support group for the formerly colonized.<br/><br/><a href="https://www.theguardian.com/world/2024/oct/26/commonwealth-heads-reparatory-justice-dialogue-despite-reluctant-uk">https://www.theguardian.com/world/2024/oct/26/commonwealth-heads-reparatory-justice-dialogue-despite-reluctant-uk</a> 2024-10-26T20:01:09Z https://yabu.me/nevent1qqszwh9jtah7kh8yn4rwfw657urjhe0v637nzs9r8gdsmn663fdvreszyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j54t8lms In reply to <a href='/nevent1qqs2xaq7k3cl3mw5ry6kjrces7a4a4q5m43fwq3pdltrf0jv4w73shgu7kls3'>nevent1q…kls3</a><br/>_________________________<br/><br/>No, I meant relaxing to have my thoughts obliterated. One by one.<br/><br/>I have a lot of thoughts. 2024-10-23T20:10:33Z https://yabu.me/nevent1qqsveuh3ksglumza6lfh77nqm5fzancmht4mcag0p6uwu7a794d88qqzyran269qs70fw8dndfumj9fkn4whpn7e6g0pndeu8fnu3wg0jz4j5se3g52 In reply to <a href='/nevent1qqs9ghpzvczdsaa3duft4mt8hq98afumxkgefkpceydpqqv48ajryeq8e53a8'>nevent1q…53a8</a><br/>_________________________<br/><br/>Okay but that sounds very relaxing. 2024-10-23T18:52:21Z